ArticleCommunications biology2020
Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function.
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Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
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39 citing papers in PubMed, 60 citations in OpenAlex.
- Exposure Pattern Determines Methamphetamine-Induced Right Ventricular Dysfunction and Vascular Remodeling.Comprehensive Physiology · 2026Article
- Subthreshold Thermal Stress Aggravates Methamphetamine-Induced Cardiomyocyte Pyroptosis via the Mitochondrial ROS/BAX/mtDNA/NLRP3 Pathway.International journal of molecular sciences · 2026Article
- Roles of gut and oral microbiota in methamphetamine-induced multi-organ toxicity.Cell biology and toxicology · 2026Review
- Role of Sigma-1 Receptors in the Paraventricular Nucleus and Myocardium during Cirrhotic Cardiomyopathy in Rats.Molecular neurobiology · 2026Article
- Bridging tradition and modernity: mitochondrial dynamics as a Traditional Chinese Medicine therapeutic target in cardiovascular disease.Chinese medicine · 2026Review
- Methamphetamine-Associated Cardiomyopathy and Cardioembolic Stroke: Brain-Heart-Gut Axis Crosstalk, Diagnostic Strategies, and Anticoagulation Challenges.International journal of molecular sciences · 2025Review
- Integrated control of cancer stemness by σOncogene · 2025Article
- Cannabidiol alleviates methamphetamine addictionActa pharmaceutica Sinica. B · 2025Article
- Fatal intoxications and inherited cardiac disorders in the young: where to draw the line?International journal of legal medicine · 2025Review
- Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats.Frontiers in pharmacology · 2025Article
- Hospitalized patients and stimulant use-associated heart failure: importance of ejection fraction and related risk factors.Frontiers in cardiovascular medicine · 2025Article
- A Mechanistic Review on Toxicity Effects of Methamphetamine.International journal of medical sciences · 2025Review
- The Sigma-1 Receptor Exacerbates Cardiac Dysfunction Induced by Obstructive Nephropathy: A Role for Sexual Dimorphism.Biomedicines · 2024Article
- Prevalence and patterns of methamphetamine use and mental health disparity in the United States.Nature. Mental health · 2024Article
- Diastolic dysfunction in Alzheimer's disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction.Scientific reports · 2024Article
- Cardiomyopathy-Associated Hospital Admissions Among Methamphetamine Users: Geographical and Social Disparities.JACC. Advances · 2024Article
- Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study.Frontiers in cardiovascular medicine · 2024Article
- Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction.Frontiers in physiology · 2024Article
- Social-geographic disparities in suicidal ideations among methamphetamine users in the USA.Psychiatry research · 2023Article
- Multi-Omics Analysis Reveals the Role of Sigma-1 Receptor in a Takotsubo-like Cardiomyopathy Model.Biomedicines · 2023Article
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Authors and funding
23 authors at 2 institutions in 1 country.
Chowdhury S AbdullahDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.ORCID 0000-0001-5771-220X
Richa AishwaryaDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Shafiul AlamDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.ORCID 0000-0001-8684-624X
Mahboob MorshedDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Naznin Sultana RemexDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Sadia NituDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Gopi K KolluruDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
James TraylorDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Sumitra MiriyalaDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.ORCID 0000-0001-7158-9295
Manikandan PanchatcharamDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.ORCID 0000-0002-7691-8948
Brandon HartmanDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Judy KingDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Mohammad Alfrad Nobel BhuiyanDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital, Cincinnati, OH, 45229, USA.
Sunitha ChandranDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Matthew D WoolardDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Xiuping YuDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Nicholas E GoedersDepartment of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Paari DominicDepartment of Medicine, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Connie L ArnoldDepartment of Medicine, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Karen StokesDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Christopher G KevilDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.ORCID 0000-0003-0863-7260
A Wayne OrrDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA.
Md Shenuarin BhuiyanDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, 71103, USA. mbhuiy@lsuhsc.edu.ORCID 0000-0003-0073-3071
Louisiana State University Health Sciences Center Shreveport · USCincinnati Children's Hospital Medical Center · US
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1MStress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Gopi K Kolluru · 2018 to 2026
$23.6MNck Adaptor Proteins in Atherogenic Endothelial ActivationR01HL133497 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2016 to 2024
$3.8MMatrix Signaling in Endothelial Cell DysfunctionR01HL098435 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2010 to 2020
$3.2MSigmar1 in lipid metabolismR01HL145753 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BHUIYAN, MD. SHENUARIN · 2019 to 2023
$2.6MEphA2 signaling in atherosclerotic fibroproliferative remodelingR01HL141155 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2019 to 2022
$1.8MCSE regulation of vascular remodelingR01HL149264 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2020 to 2023
$1.7MMacrophage- associated lipin-1 lipid synthesis regulates foam cell inflammatory responsesR01HL131844 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI WOOLARD, MATTHEW DALE · 2017 to 2020
$1.4MSigma-1 receptor and cardioprotectionR00HL122354 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BHUIYAN, MD. SHENUARIN · 2015 to 2017
$747kPrenatal ethanol mediated regulation of bioactive lipid: Role of Autotaxin and LPP3 in Alzheimer disease.R15HL141998 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI MIRIYALA, SUMITRA · 2018 to 2019
$508kAlcohol-LPP3 axis in ischemic strokeR21AA025744 · NIAAA · LOUISIANA STATE UNIV HSC SHREVEPORT · PI PANCHATCHARAM, MANIKANDAN · 2017 to 2018
$483kAlcohol mediated myocardial lysophosphatidic acid signalingR21AA026708 · NIAAA · LOUISIANA STATE UNIV HSC SHREVEPORT · PI PANCHATCHARAM, MANIKANDAN · 2020 to 2021
$383kAmerican Heart Association-American Stroke Association 18POST34080495American Heart Association-American Stroke Association 20POST35210789 - CHOWDHURY ABDULLAHNHLBI NIH HHS HL122354NHLBI NIH HHS HL145753NHLBI NIH HHS HL145753-01S1NHLBI NIH HHS K99 HL122354NHLBI NIH HHS R00 HL122354NHLBI NIH HHS R01 HL098435NHLBI NIH HHS R01 HL131844NHLBI NIH HHS R01 HL133497NHLBI NIH HHS R01 HL141155NHLBI NIH HHS R01 HL145753NHLBI NIH HHS R01 HL149264NHLBI NIH HHS R15 HL141998NIAAA NIH HHS R21 AA025744NIAAA NIH HHS R21 AA026708NIGMS NIH HHS P20 GM121307NIGMS NIH HHS U54 GM104940
Abstract
Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of "binge and crash" methamphetamine administration. Sigmar1 expression is significantly decreased in the hearts of human methamphetamine users and those of "binge and crash" methamphetamine-treated mice. The hearts of methamphetamine users also show signs of cardiomyopathy, including cellular injury, fibrosis, and enlargement of the heart. In addition, mice expose to "binge and crash" methamphetamine develop cardiac hypertrophy, fibrotic remodeling, and mitochondrial dysfunction leading to contractile dysfunction. Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Therefore, Sigmar1 is a viable therapeutic agent for protection against methamphetamine-associated cardiomyopathy.
Indexed as
AnimalsCardiomyopathiesCyclic AMP Response Element-Binding ProteinDrug Administration ScheduleGene Expression RegulationHeartHumansMethamphetamineMiceMitochondriaMitochondrial ProteinsMyocardiumMyocytes, CardiacReceptors, sigmaSigma-1 ReceptorCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinFIS1 protein, mouseMethamphetamineMitochondrial ProteinsReceptors, sigmaSigma-1 Receptor
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