ArticlePediatric research2021
Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Executive function after childhood cancer: Insights from network neuroscience.Neuro-oncology advances · 2026Review
- CSF metabolomic signature during therapy for childhood acute lymphoblastic leukemia predicts subsequent working memory impairment.Molecular medicine (Cambridge, Mass.) · 2025Article
- Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice.Acta neuropathologica communications · 2025Article
- DNA methylation alterations in acute lymphoblastic leukemia survivors with late neurocognitive deficits.Leukemia · 2025Article
- Probiotic supplementation attenuated early-life chemotherapy-induced brain development impairment in mice.Frontiers in behavioral neuroscience · 2025Article
- Identifying fine motor difficulties in children with acute lymphoblastic leukemia: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Identifying patterns of neurocognitive dysfunction through direct comparison of children with leukemia, central nervous system tumors, and sickle cell disease.Pediatric blood & cancer · 2023Article
- Characterizing academic performance in pediatric acute lymphoblastic leukemia with population-based achievement tests.Cancer reports (Hoboken, N.J.) · 2022Article
- Association between fatigue and sleep disturbances during treatment for pediatric acute lymphoblastic leukemia and posttreatment neurocognitive performance.Pediatric blood & cancer · 2022Article
- Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate.Neuropharmacology · 2022Article
- Characterizing Early Changes in Quality of Life in Young Women With Breast Cancer.Frontiers in psychology · 2022Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWith high survival rates for pediatric acute lymphoblastic leukemia (ALL), long-term quality of life is a prominent consideration in treatment. We concurrently evaluated cognition, behavior, and quality of life in child and adolescent ALL survivors and determined associations between them.
methodsThe sample included 83 controls (mean age: 12.5 years) and 71 ALL survivors (mean age: 11.9 years, mean age at diagnosis: 3.8 years). Participants completed measures of general intellectual abilities, math achievement, and fine motor skills. Parents and teachers completed a survey assessing child participants' cognitive, behavioral, and emotional function. Parents additionally completed a survey about their child's quality of life.
resultsSurvivors had lower scores on measures of working memory, processing speed, timed math, and fine motor skills (effect size 0.5-1, p < 0.001). Parents identified more problems with executive function and learning in survivors than controls (effect size > 0.7, p < 0.001), and indicated a lower quality of life in all categories evaluated (effect size > 0.7, p < 10
conclusionsALL survivors experience diffuse cognitive, behavioral, and motor impairments, which are associated with reduced quality of life. These findings underscore the need to address these challenges in ALL survivors. IMPACT: Compared with cancer-free peers, parents of childhood acute lymphoblastic leukemia survivors treated with chemotherapy only reported reduced quality of life. Math difficulties and behavioral problems increased the risk for reduced quality of life. Reduced quality of life is associated with mild cognitive and behavioral difficulties, suggesting that even relatively mild impairments have broad implications for ALL survivors. Screening and early intervention targeting cognitive and behavioral function may enhance quality of life for ALL survivors.
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