ArticleScientific reports2020
Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Transient acute kidney injury following femoral fracture in mice : the role of sympathetic activation.Bone & joint research · 2026Article
- Validation of biomarker-based stratification for risk of long-term outcomes after acute kidney injury.Clinical kidney journal · 2026Article
- Trauma Preconditioning of Cytokine Response: Comparison of Perioperative Cytokine Profiles in Elective Cardiac versus Orthopaedic Trauma Surgery Patients.International journal of nephrology and renovascular disease · 2026Article
- Determinants of effectiveness in orthopedic ERAS: a cross-setting perspective based on the integration of nutritional status and clinical outcomes.Frontiers in nutrition · 2026Article
- Use of a BMI-independent biomarker-based prostate cancer risk score to identify and triage individuals at risk of prostate disease.Scientific reports · 2025Article
- The Epidemiology and Outcomes of Acute Kidney Injury in Patients With Chronic Kidney Disease: A Single-Center Retrospective Cohort Study.Anesthesiology research and practice · 2025Article
- Blood and urinary cytokine balance and renal outcomes at orthopaedic surgery.Frontiers in endocrinology · 2024Article
- Streamlining orthopaedic trauma surgical care: do all patients need medical clearance?Archives of orthopaedic and trauma surgery · 2023Article
- Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- A new model to predict acute kidney injury after cardiac surgery in patients with renal insufficiency.Renal failure · 2022Article
- A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers.Scientific reports · 2022Article
- Non-alcoholic fatty liver disease-A pilot study investigating early inflammatory and fibrotic biomarkers of NAFLD with alcoholic liver disease.Frontiers in physiology · 2022Article
- A Novel Combination of Serum Markers in a Multivariate Model to Help Triage Patients Into "Low-" and "High-Risk" Categories for Prostate Cancer.Frontiers in oncology · 2022Article
- Biomarkers for Detecting Kidney Dysfunction in Type-2 Diabetics and Diabetic Nephropathy Subjects: A Case-Control Study to Identify Potential Biomarkers of DN to Stratify Risk of Progression in T2D Patients.Frontiers in endocrinology · 2022Article
- Biomarkers to assess the risk of bladder cancer in patients presenting with haematuria are gender-specific.Frontiers in oncology · 2022Article
- Developing an Agnostic Risk Prediction Model for Early AKI Detection in Cancer Patients.Cancers · 2021Article
- Panax Ginseng C.A.Mey. as Medicine: The Potential Use of Panax Ginseng C.A.Mey. as a Remedy for Kidney Protection from a Pharmacological Perspective.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patients are at risk of AKI. This is a prospective study of 237 orthopaedic trauma patients who were consecutively scheduled for open reduction and internal fixation of their fracture between May 2012 and August 2013. Clinical characteristics were recorded, and 28 biomarkers were analysed in patient blood samples. Post operatively a combination of H-FABP, sTNFR1 and MK had the highest predictive ability to identify patients at risk of developing AKI (AUROC 0.885). Three clinical characteristics; age, dementia and hypertension were identified in the orthopaedic trauma patients as potential risks for the development of AKI. Combining biomarker data with clinical characteristics allowed us to develop a proactive AKI clinical tool, which grouped patients into four risk categories that were associated with a clinical management regime that impacted patient care, management, length of hospital stay, and efficient use of hospital resources.
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