ArticleScientific reports2020
Extraction of flavanones from immature Citrus unshiu pomace: process optimization and antioxidant evaluation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
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- Immature Citrus unshiu fruit extracts inhibit adipogenesis in 3T3-L1 adipocytes via AMPK and MAPK signaling pathways.PloS one · 2025Article
- Use of micronised apple and mandarin bagasse for emulsion stabilisation.Current research in food science · 2025Article
- Jeju Citrus (International journal of molecular sciences · 2024Article
- Sequential Extraction and Characterization of Essential Oil, Flavonoids, and Pectin from Industrial Orange Waste.ACS omega · 2024Article
- Anti-inflammatory effects of immatureFood science and biotechnology · 2024Article
- Effects of polystyrene microplastics on the growth and metabolism of highland barley seedlings based on LC-MS.Frontiers in plant science · 2024Article
- GenusPlants (Basel, Switzerland) · 2023Review
- A Two-Step Approach to Orange Peel Waste Valorization: Consecutive Extraction of Pectin and Hesperidin.Foods (Basel, Switzerland) · 2023Article
- Elucidation of flavanones, phenols and antioxidant capacity influenced by drying methods from physiologically dropped underutilizedFrontiers in plant science · 2023Article
- Extraction Optimization, Preliminary Identification, and Bioactivities in Corn Silk.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Lid scrubbing with a gel combining natural extracts for dry eye treatment.International journal of ophthalmology · 2023Article
- Antioxidant activities of premature and mature mandarin (Food science and biotechnology · 2022Article
- Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits.Scientific reports · 2022Article
- Valorization of Taiwan'sCurrent research in food science · 2022Article
- Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells.Journal of veterinary science · 2022Article
- Determination of experimental domain factors of polyphenols, phenolic acids and flavonoids of lemonSaudi journal of biological sciences · 2022Article
- Composition, anti-LDL oxidation, and non-enzymatic glycosylation inhibitory activities of the flavonoids fromFrontiers in nutrition · 2022Article
- Organic Acid-Catalyzed Subcritical Water Hydrolysis of ImmatureFoods (Basel, Switzerland) · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Dietary guidelines recommend the consumption of flavonoid-rich extracts for several health benefits. Although immature Citrus unshiu pomace (ICUP) contains high levels of flavanone glycosides, many studies have concentrated on the optimization of flavonoid extraction from mature citrus peels. Therefore, we developed an optimized extraction method for hesperidin and narirutin from ICUP, and evaluated their antioxidant activities using ten different assay methods. The extraction conditions for the highest flavonoid yields based on a response surface methodology were 80.3 °C, 58.4% (ethanol concentration), 40 mL/g (solvent/feed), and 30 min, where the hesperidin and narirutin yields were 66.6% and 82.3%, respectively. The number of extractions was also optimized as two extraction steps, where the hesperidin and narirutin yields were 92.1% and 97.2%, respectively. Ethanol was more effective than methanol and acetone. The ethanol extract showed high scavenging activities against reactive oxygen species but relatively low scavenging activities for nitrogen radicals and reactive nitrogen species. The antioxidant activities showed a higher correlation with hesperidin content than narirutin content in the extracts. This study confirms the potential of an optimized method for producing antioxidant-rich extracts for the functional food and nutraceutical industries.
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