Evidence map›Paper›PMID 33203917›Full record

ArticleScientific reports2020

Ecological drivers of genetic connectivity for African malaria vectors Anopheles gambiae and An. arabiensis.

Elizabeth Hemming-Schroeder, Daibin Zhong, Maxwell Machani, Hoan Nguyen, Sarah Thong, Samuel Kahindi, Charles Mbogo, Harrysone Atieli, Andrew Githeko, Tovi Lehmann and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elizabeth Hemming-SchroederDepartment of Ecology and Evolutionary Biology and Program in Public Health, University of California, Irvine, CA, 92617, USA.
Daibin ZhongDepartment of Ecology and Evolutionary Biology and Program in Public Health, University of California, Irvine, CA, 92617, USA.
Maxwell MachaniCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Hoan NguyenDepartment of Ecology and Evolutionary Biology and Program in Public Health, University of California, Irvine, CA, 92617, USA.
Sarah ThongDepartment of Ecology and Evolutionary Biology and Program in Public Health, University of California, Irvine, CA, 92617, USA.
Samuel KahindiSchool of Pure and Applied Sciences, Pwani University, Kilifi, Kenya.
Charles MbogoCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Harrysone AtieliCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Andrew GithekoCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Tovi LehmannLaboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, 20892, USA.
James W KazuraCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, 44106, USA.
Guiyun YanDepartment of Ecology and Evolutionary Biology and Program in Public Health, University of California, Irvine, CA, 92617, USA. guiyuny@hs.uci.edu.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
Vector Biology of Invasive Anopheles stephensi in Rural to Urban Landscapes in EthiopiaU19AI129326 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2017 to 2026
$19.9M
Ecology of African Highland MalariaR01AI050243 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI YAN, GUIYUN · 2001 to 2018
$8.8M
Research Training in Mosquito Genomics and Bioinformat*D43TW001505 · FIC · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2000 to 2026
$6.0M
Molecular epidemiology and serology of malaria under shifting agricultural practices in AfricaF32AI147460 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI HEMMING-SCHROEDER, ELIZABETH ANNE · 2019 to 2022
$171k
FIC NIH HHS D43 TW001505NCATS NIH HHS UL1 TR001414NIAID NIH HHS F32 AI147460NIAID NIH HHS L60 AI154505NIAID NIH HHS R01 AI050243NIAID NIH HHS U19 AI089672NIAID NIH HHS U19 AI129326NIH HHS F32AI147460NIH HHS U19AI129326
6 · The paper itself

Abstract

Anopheles gambiae and An. arabiensis are major malaria vectors in sub-Saharan Africa. Knowledge of how geographical factors drive the dispersal and gene flow of malaria vectors can help in combatting insecticide resistance spread and planning new vector control interventions. Here, we used a landscape genetics approach to investigate population relatedness and genetic connectivity of An. gambiae and An. arabiensis across Kenya and determined the changes in mosquito population genetic diversity after 20 years of intensive malaria control efforts. We found a significant reduction in genetic diversity in An. gambiae, but not in An. arabiensis as compared to prior to the 20-year period in western Kenya. Significant population structure among populations was found for both species. The most important ecological driver for dispersal and gene flow of An. gambiae and An. arabiensis was tree cover and cropland, respectively. These findings highlight that human induced environmental modifications may enhance genetic connectivity of malaria vectors.

Indexed as

Genetics, PopulationGenetic VariationAnimalsAnophelesHumansInsecticide ResistanceKenyaMalariaMalaria, FalciparumMosquito Vectors

Identifiers

PMID33203917
PMCPMC7673128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.