ArticleNature communications2020
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 3 of them syntheses that pooled it.
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192citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
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Who cites it
192 citing papers in PubMed, 3 syntheses or guidelines pooled it, 289 citations in OpenAlex.
- Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters.EBioMedicine · 2023Pooled it
- Severe acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review.Reviews in medical virology · 2021Pooled it
- Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review.Critical care (London, England) · 2020Pooled it
- Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.EBioMedicine · 2021Trial
- Multi-antigen coronavirus vaccine induces potent and durable cross-protection against multiple SARS-CoV-2 variants.NPJ vaccines · 2026Article
- Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression.Nature communications · 2026Article
- Optimized Contrast-Enhanced Micro-Computed Tomography for Simultaneous Imaging of the Ductus Arteriosus and Pulmonary Arteries During the Perinatal Transition.Pulmonary circulation · 2026Article
- 2-Phenylquinolines Exhibit Anti-Severe Acute Respiratory Syndrome Coronavirus-2 Activity Through the Nonstructural Protein 13 Helicase Inhibition.ChemMedChem · 2026Article
- Review
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- COVID-19-related inflammation of the placenta impedes fetal development in pregnant hamsters.Nature communications · 2026Article
- When less is statistically Equivalent: Lobe-Specific optimization of histopathological assessment in SARS-CoV-2 pneumonia.Computers in biology and medicine · 2025Article
- Review
- An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters.Scientific reports · 2025Article
- Article
- Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases.BMC genomics · 2025Article
- Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.Journal of medicinal chemistry · 2025Article
- Optimization of SARS-CoV-2 MInternational journal of molecular sciences · 2025Article
- Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters.Frontiers in immunology · 2025Article
- Antigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19.Microorganisms · 2024Article
132 more citing papers are in PubMed but not listed here.
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Authors and funding
51 authors at 5 institutions in 3 countries.
Robbert BoudewijnsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-5984-7279
Hendrik Jan ThibautLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. hendrikjan.thibaut@kuleuven.be.ORCID 0000-0001-5785-8276
Suzanne J F KapteinLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-7935-0219
Rong LiDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Valentijn VergoteLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-4436-3212
Laura SeldeslachtsKU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Johan Van WeyenberghLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Carolien De KeyzerLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Lindsey BervoetsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Sapna SharmaLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0003-3493-252X
Laurens LiesenborghsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0001-5616-8548
Ji MaLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Sander JansenLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-9344-131X
Dominique Van LooverenLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Thomas VercruysseLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Xinyu WangLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Dirk JochmansLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-9265-6028
Erik MartensImmunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Kenny RooseVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.ORCID 0000-0002-5270-4603
Dorien De VliegerVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.
Bert SchepensVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.
Tina Van BuytenLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Sofie JacobsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0001-8657-6841
Yanan LiuDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Joan Martí-CarrerasLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-0005-9761
Bert VanmechelenLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-8350-4356
Tony Wawina-BokalangaLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Leen DelangLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-8874-675X
Joana Rocha-PereiraLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Lotte CoelmontLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Winston ChiuLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0001-5236-623X
Pieter LeyssenLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Elisabeth HeylenLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0003-4359-7225
Dominique ScholsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Lanjiao WangLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Lila CloseLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Jelle MatthijnssensLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0003-1188-9733
Marc Van RanstLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Veerle CompernolleBlood Service, Belgian Red Cross Flanders, Mechelen, Belgium.
Georg SchrammKU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.ORCID 0000-0002-2251-3195
Koen Van LaereKU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.ORCID 0000-0001-5200-7245
Xavier SaelensVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.ORCID 0000-0002-3861-6965
Nico CallewaertVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.ORCID 0000-0003-2069-6917
Ghislain OpdenakkerImmunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0003-1714-2294
Piet MaesLaboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.ORCID 0000-0002-4571-5232
Birgit WeynandKU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.ORCID 0000-0003-4246-6303
Christopher CawthorneKU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.ORCID 0000-0002-5975-0354
Greetje Vande VeldeKU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.ORCID 0000-0002-5633-3993
Zhongde WangDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.ORCID 0000-0003-2441-4729
Johan NeytsLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. johan.neyts@kuleuven.be.ORCID 0000-0002-0033-7514
Kai DallmeierLaboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. kai.dallmeier@kuleuven.be.ORCID 0000-0002-8117-9166
Rega Institute for Medical Research · BEGhent University · BEKU Leuven · BEUtah State University · USEuropean Union · BE
Funding
Wellcome Trust
Abstract
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice. Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
Indexed as
Disease Models, AnimalSignal TransductionAnimalsBetacoronavirusCoronavirus InfectionsCOVID-19CricetinaeImmunity, InnateInterferon Type ILungMicePandemicsPneumonia, ViralSARS-CoV-2STAT2 Transcription FactorVirus ReplicationInterferon Type ISTAT2 Transcription Factor
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