ArticleNature communications2020
FIS1 encodes a GA2-oxidase that regulates fruit firmness in tomato.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 116 citations in OpenAlex.
- The novel function of the bZIP transcription factor VSF-1 in mediating fruit firmness in tomato.Horticulture research · 2026Article
- Fine mapping and candidate genes analysis for flesh thickness major locusHorticulture research · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Fine-mapping and candidate gene analysis of qFF3.1 conferring fruit firmness in a modern tomato variety.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Association mapping of tomato fruit quality for weight, firmness, brix, and color using GWAS.BMC plant biology · 2025Article
- CRISPR-Cas9: Unraveling Genetic Secrets to Enhance Floral and Fruit Traits in Tomato.Molecular biotechnology · 2025Review
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- Histological and Transcriptomic Insights into Rugose Surface Formation in Pepper (Plants (Basel, Switzerland) · 2025Article
- ENDOGLUCANASE SlCEL2 and EXPANSIN SlEXP1 synergistically affect cellulose degrading and tomato fruit softening.BMC plant biology · 2025Article
- Tonoplast sugar transporters coordinately regulate tomato fruit development and quality.Plant communications · 2025Article
- A feedback loop at the THERMOSENSITIVE PARTHENOCARPY 4 locus controls tomato fruit set under heat stress.Nature communications · 2025Article
- Identifying Candidate Genes for Grape (Journal of agricultural and food chemistry · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- CRISPR/cas9 Allows for the Quick Improvement of Tomato Firmness Breeding.Current issues in molecular biology · 2024Article
- A natural variant of NON-RIPENING promotes fruit ripening in watermelon.The Plant cell · 2024Article
- Quality and Safety in Asparagus Cultivation: A Three-Year Case Study Comparing Standardized Agricultural Bases and Small-Scale Farmers.ACS omega · 2024Article
- Genome-Wide Association Study of Grape Texture Based on Puncture.International journal of molecular sciences · 2024Article
- Article
- A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes.Nature communications · 2024Article
- Exploring the influence of a single-nucleotide mutation in EIN4 on tomato fruit firmness diversity through fruit pericarp microstructure.Plant biotechnology journal · 2024Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fruit firmness is a target trait in tomato breeding because it facilitates transportation and storage. However, it is also a complex trait and uncovering the molecular genetic mechanisms controlling fruit firmness has proven challenging. Here, we report the map-based cloning and functional characterization of qFIRM SKIN 1 (qFIS1), a major quantitative trait locus that partially determines the difference in compression resistance between cultivated and wild tomato accessions. FIS1 encodes a GA2-oxidase, and its mutation leads to increased bioactive gibberellin content, enhanced cutin and wax biosynthesis, and increased fruit firmness and shelf life. Importantly, FIS1 has no unfavorable effect on fruit weight or taste, making it an ideal target for breeders. Our study demonstrates that FIS1 mediates gibberellin catabolism and regulates fruit firmness, and it offers a potential strategy for tomato breeders to produce firmer fruit.
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