Evidence map›Paper›PMID 33203829›Full record

ArticleBlood cancer journal2020

Functional validation of TERT and TERC variants of uncertain significance in patients with short telomere syndromes.

Alejandro Ferrer, Abhishek A Mangaonkar, Susanna Stroik, Michael T Zimmermann, Ashley N Sigafoos, Patrick S Kamath, Douglas A Simonetto, Mark E Wylam, Eva M Carmona, Konstantinos N Lazaridis and 5 more

Open access · goldAbstract readCase ReportsLetterValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Alejandro FerrerCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4883-3023
Abhishek A MangaonkarDepartment of Hematology, Mayo Clinic, Rochester, MN, USA.
Susanna StroikDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Michael T ZimmermannGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Wauwatosa, USA.ORCID 0000-0001-7073-0525
Ashley N SigafoosDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Patrick S KamathDepartment of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Douglas A SimonettoDepartment of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Mark E WylamPulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Eva M CarmonaPulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Konstantinos N LazaridisCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Steve PetersPulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Keith StewartCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Eric W KleeCenter for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Eric A HendricksonDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. hendr064@umn.edu.ORCID 0000-0001-6734-6426
Mrinal M PatnaikDepartment of Hematology, Mayo Clinic, Rochester, MN, USA. patnaik.mrinal@mayo.edu.ORCID 0000-0001-6998-662X
Mayo Clinic · USMayo Clinic in Florida · USMedical College of Wisconsin · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

Ligase III regulates survival from crisis induced by gradual telomere shorteningR01CA190492 · NCI · UNIVERSITY OF MINNESOTA · PI HENDRICKSON, ERIC A · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA190492
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Telomere ShorteningAdultAgedFemaleHumansMaleMiddle AgedRNASyndromeTelomeraseRNATelomerasetelomerase RNATERT protein, human

Identifiers

PMID33203829
PMCPMC7673118
OpenAlexW3106464698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.