Evidence map›Paper›PMID 33203757›Full record

ArticlemBio2020

Characterization of Posttranslationally Modified Multidrug Efflux Pumps Reveals an Unexpected Link between Glycosylation and Antimicrobial Resistance.

Sherif Abouelhadid, John Raynes, Tam Bui, Jon Cuccui, Brendan W Wren

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Glycoconjugate diversification inbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Glycoproteomic and proteomic analysis ofMicrobiology spectrum · 2024
    Article
  9. Multi-Omics ofMicroorganisms · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. CRISPRi-Mediated Silencing ofJournal of proteome research · 2023
    Article
  14. Article
  15. Article
  16. Glycobiology of Cancer: Sugar Drives the Show.Medicines (Basel, Switzerland) · 2022
    Article
  17. Applied and environmental microbiology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sherif AbouelhadidDepartment of Pathogen Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
John RaynesDepartment of Pathogen Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Tam BuiBiomolecular Spectroscopy Centre, King's College London, Hodgkin, United Kingdom.
Jon CuccuiDepartment of Pathogen Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Brendan W WrenDepartment of Pathogen Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom brendan.wren@lshtm.ac.uk.ORCID 0000-0002-6140-9489
University of London · GBKing's College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/F009321/1Biotechnology and Biological Sciences Research Council E20372Wellcome Trust 102978/Z/13/ZWellcome Trust 102979/Z/13/Z
6 · The paper itself

Abstract

The substantial rise in multidrug-resistant bacterial infections is a current global imperative. Cumulative efforts to characterize antimicrobial resistance in bacteria has demonstrated the spread of six families of multidrug efflux pumps, of which resistance-nodulation-cell division (RND) is the major mechanism of multidrug resistance in Gram-negative bacteria. RND is composed of a tripartite protein assembly and confers resistance to a range of unrelated compounds. In the major enteric pathogen

Indexed as

Drug Resistance, Multiple, BacterialProtein Processing, Post-TranslationalProteomeAnti-Bacterial AgentsATP Binding Cassette Transporter, Subfamily BBacterial ProteinsCampylobacterCampylobacter InfectionsCampylobacter jejuniGlycosylationVirulence FactorsAnti-Bacterial AgentsATP Binding Cassette Transporter, Subfamily BBacterial ProteinsProteomeVirulence Factorsglycosylationmultidrug efflux pumpN-linked glycans

Identifiers

PMID33203757
PMCPMC7683400
OpenAlexW3105293689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.