Evidence map›Paper›PMID 33203675›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA.

Fengwei Zheng, Roxana E Georgescu, Huilin Li, Michael E O'Donnell

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanistic diversity of clamp loading at small DNA gaps.The Journal of biological chemistry · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. ThebioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
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  14. Microbiology spectrum · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Z-form DNA-RNA hybrid blocks DNA replication.Nucleic acids research · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fengwei ZhengStructural Biology Program, Van Andel Institute, Grand Rapids, MI 49503.ORCID 0000-0002-7139-4831
Roxana E GeorgescuDNA Replication Laboratory, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-1882-2358
Huilin LiStructural Biology Program, Van Andel Institute, Grand Rapids, MI 49503; Huilin.Li@vai.org odonnel@rockefeller.edu.ORCID 0000-0001-8085-8928
Michael E O'DonnellDNA Replication Laboratory, The Rockefeller University, New York, NY 10065; Huilin.Li@vai.org odonnel@rockefeller.edu.ORCID 0000-0001-9002-4214
Rockefeller University · USVan Andel Institute · US

Funding

Structural mechanism of DNA replicationR35GM131754 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2019 to 2026
$6.0M
Biochemical Mechanism and Structure of the Eukaryotic Replication ForkR01GM115809 · NIGMS · ROCKEFELLER UNIVERSITY · PI O'DONNELL, MICHAEL E · 2015 to 2022
$2.6M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM115809NIGMS NIH HHS R35 GM131754
6 · The paper itself

Abstract

The DNA polymerase (Pol) δ of

Indexed as

Cryoelectron MicroscopyDideoxynucleotidesDNADNA Polymerase IIIIron-Sulfur ProteinsModels, MolecularMutationNeoplasmsProliferating Cell Nuclear AntigenProtein BindingProtein SubunitsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThymine Nucleotides2',3'-dideoxythymidine triphosphateDideoxynucleotidesDNADNA Polymerase IIIIron-Sulfur ProteinsOkazaki fragmentsProliferating Cell Nuclear AntigenProtein SubunitsSaccharomyces cerevisiae ProteinsThymine NucleotidesDNA polymeraseDNA polymerase δDNA replicationPCNAsliding clamp

Identifiers

PMID33203675
PMCPMC7720213
OpenAlexW3100171747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.