Evidence map›Paper›PMID 33203475›Full record

ArticleGenome biology2020

Stairway Plot 2: demographic history inference with folded SNP frequency spectra.

Xiaoming Liu, Yun-Xin Fu

Erratum issuedAbstract read
In one paragraph

Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 215 papers.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

215 citing papers in PubMed.

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  19. Population Collapse of the Spidery Wattle (Ecology and evolution · 2026
    Article
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xiaoming LiuUSF Genomics & College of Public Health, University of South Florida, Tampa, FL, USA. xiaomingliu@usf.edu.ORCID 0000-0001-8285-5528
Yun-Xin FuDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

Accurately Inferring Demographic Histories of Human Populations Using Large Whole Genome Sequence DataR01HG009524 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, XIAOMING · 2017 to 2020
$1.3M
NHGRI NIH HHS R01 HG009524
6 · The paper itself

Abstract

Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra. It is based on a nonparametric method with the capability of handling folded SNP frequency spectra (that is, when the ancestral alleles of the SNPs are unknown) of thousands of samples produced with genotyping-by-sequencing technologies; therefore, it is particularly suitable for nonmodel organisms.

Indexed as

DemographyGenomicsPolymorphism, Single NucleotideAllelesGenotyping TechniquesHumansModels, Genetic

Identifiers

PMID33203475
PMCPMC7670622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.