Evidence map›Paper›PMID 33203297›Full record

ArticleJournal of neurotrauma2021

Estrogen Alleviates Sex-Dependent Differences in Lung Bacterial Clearance and Mortality Secondary to Bacterial Pneumonia after Traumatic Brain Injury.

Jean-Francois Pittet, Parker J Hu, Jaideep Honavar, Angela P Brandon, Cilina A Evans, Rebekah Muthalaly, Qiang Ding, Brant M Wagener

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Estrogen and bacterial infection.Frontiers in immunology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jean-Francois PittetDivisions of Critical Care Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Parker J HuDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jaideep HonavarMolecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Angela P BrandonMolecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Cilina A EvansMolecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Rebekah MuthalalyMolecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Qiang DingMolecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brant M WagenerDivisions of Critical Care Medicine and University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

NWASP regulates neuroinflammation and cognition in Alzheimer's diseaseR01HL143017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DING, QIANG, PITTET, JEAN-FRANCOIS · 2018 to 2021
$2.2M
The Impaired FRNK in IPFR01HL152183 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DING, QIANG · 2021 to 2024
$2.2M
The Role of Sex Dimorphism in Post-TBI Bacterial PneumoniaR01GM127584 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAGENER, BRANT M · 2018 to 2022
$1.9M
The Role of ZFP36 in Control of IPFR01HL127338 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DING, QIANG · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL127338NHLBI NIH HHS R01 HL143017NHLBI NIH HHS R01 HL152183NIGMS NIH HHS R01 GM127584
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is the leading cause of injury-related death and disability in patients under the age of 46 years. Survivors of the initial injury often endure systemic complications such as pulmonary infection, and

Indexed as

Sex CharacteristicsAnimalsBrain Injuries, TraumaticCell LineEstradiolFemaleLungMaleMiceMice, Inbred C57BLPneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsTumor Necrosis Factor-alphaEstradiolTumor Necrosis Factor-alphamacrophagephagocytosisPseudomonas aeruginosasex dimorphismtumor necrosis factor-α

Identifiers

PMID33203297
PMCPMC8054512
OpenAlexW3101309904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.