Evidence map›Paper›PMID 33203296›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Age-related impairment of cerebral blood flow response to K

Dong Liu, Ismayil Ahmet, Brandon Griess, David Tweedie, Nigel H Greig, Mark P Mattson

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. KFrontiers in neurology · 2024
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. CRTC1 is a potential target to delay aging-induced cognitive deficit by protecting the integrity of the blood-brain barrier via inhibiting inflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  11. Review
  12. Pharmaceutical biology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dong LiuDrug Design & Development Section, Translational Gerontology Branch, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
Ismayil AhmetLaboratory of Cardiovascular Science, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
Brandon GriessLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
David TweedieDrug Design & Development Section, Translational Gerontology Branch, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
Nigel H GreigDrug Design & Development Section, Translational Gerontology Branch, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.
National Institute on Aging · US

Funding

Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)ZIAAG000311 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2009 to 2025
$16.0M
ALZHEIMERS RESEARCH PROJECT: Alzheimer's disease drug developmentZIAAG000469 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2019 to 2025
$6.7M
6 · The paper itself

Abstract

Local cerebral blood flow (CBF) responses to neuronal activity are essential for cognition and impaired CBF responses occur in Alzheimer's disease (AD). In this study, regional CBF (rCBF) responses to the K

Indexed as

Cerebrovascular CirculationMutationAge FactorsAlzheimer DiseaseAnimalsBrainDiazoxideKATP ChannelsMaleMiceMice, TransgenicPresenilin-1Vasodilator AgentsDiazoxideKATP ChannelsPresenilin-1Vasodilator Agents3xTgAD and PS1M146V miceamyloid-β oligomerscerebral blood flow responseeNOSKATP channel opener diazoxide

Identifiers

PMID33203296
PMCPMC8221766
OpenAlexW3104209014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.