ArticleJournal of personalized medicine2020
Ocular Vascular Changes in Mild Alzheimer's Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis.
Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images.Journal of Alzheimer's disease reports · 2023Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Retinal Microvascular Changes in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in aging neuroscience · 2022Pooled it
- A Systematic Review and Meta-Analysis of Retinal Microvascular Features in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Pooled it
- A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- A multimodal retinal aging clock for biological age prediction and systemic health assessment via OCT and fundus imaging.Scientific reports · 2026Article
- Assessment of Macular Choroidal Thickness via Enhanced Depth Imaging Optical Coherence Tomography in Patients With Chronic Tinnitus.Journal of ophthalmology · 2026Article
- Review
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer's disease.Scientific reports · 2025Article
- Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults.Journal of the American Heart Association · 2025Article
- Optical Coherence Tomography in Huntington's Disease-A Potential Future Biomarker for Neurodegeneration?Neurology international · 2025Review
- Retinal microvascular density and inner thickness in Alzheimer's disease and mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort.Alzheimer's research & therapy · 2024Article
- Feature-Based Classification of Mild Cognitive Impairment and Alzheimer's Disease Based on Optical Coherence Tomographic Angiographic Image.Sensors (Basel, Switzerland) · 2024Article
- Unlocking the Potential of Vessel Density and the Foveal Avascular Zone in Optical Coherence Tomography Angiography as Biomarkers in Alzheimer's Disease.Healthcare (Basel, Switzerland) · 2024Review
- Retinal Vascular and Structural Changes in the Murine Alzheimer'sBiomolecules · 2024Article
- Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease.Journal of clinical medicine · 2024Review
- Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer's disease: a cross-section study using optical coherence tomography angiography.Alzheimer's research & therapy · 2024Article
- Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
In Alzheimer's disease (AD), vascular changes could be caused by amyloid beta (Aβ) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are related to decreased vascular density and low blood flow. In patients with Alzheimer's disease, thinning of the choroid and the retina has been shown. The aim of this prospective study was to assess the retinal and choroidal vascular systems, analyzing the choroidal thickness with optical coherence tomography (OCT), the foveal avascular zone (FAZ) with OCT-angiography (OCTA), and the optic nerve head (ONH) hemoglobin with the Laguna ONhE program, to evaluate which of the two ocular vascular systems shows earlier changes in mild AD patients. These patients, compared to controls, showed a significantly thinner choroid at all the analyzed points, with the exception of the temporal macula (at 1000 and 1500 µm from the fovea). On the other hand, the FAZ and ONH hemoglobin did not show significant differences. In conclusion, a thinner choroid was the main ocular vascular change observed in mild AD patients, while the retinal vessels were not yet affected. Therefore, choroidal thickness could be used an early biomarker in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.