Evidence map›Paper›PMID 33203123›Full record

ArticleBiomolecules2020

Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants.

Hafsa Amat-Ur-Rasool, Fenella Symes, David Tooth, Larissa-Nele Schaffert, Ekramy Elmorsy, Mehboob Ahmed, Shahida Hasnain, Wayne G Carter

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

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  16. Cholinesterase Research.Biomolecules · 2021
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  17. Valorisation ofFoods (Basel, Switzerland) · 2021
    Article
  18. Guava (Foods (Basel, Switzerland) · 2021
    Review
  19. The Wonderful Activities of the GenusMolecules (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Hafsa Amat-Ur-RasoolSchool of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE22 3DT, UK.ORCID 0000-0001-9664-3796
Fenella SymesSchool of Pharmacy, University of Nottingham, Nottingham NG7 2UH, UK.
David ToothSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.
Larissa-Nele SchaffertSchool of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE22 3DT, UK.
Ekramy ElmorsySchool of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE22 3DT, UK.ORCID 0000-0002-7444-2499
Mehboob AhmedDepartment of Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.ORCID 0000-0002-6363-9050
Shahida HasnainDepartment of Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
Wayne G CarterSchool of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE22 3DT, UK.ORCID 0000-0003-1475-2476
University of Nottingham · GBUniversity of the Punjab · PK

Funding

Commonwealth Scholarship Commission PKCN-2018-267Higher Education Commision, Pakistan 315-78152BS3-096Higher Education Commission, Pakistan IRSIP No.1-8 /HEC/ HRD/2018/8570Higher Education Commission, Pakistan NRPU Grant 8288
6 · The paper itself

Abstract

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase inhibitors (ChEIs) are required. Herein, we screened methanolic extracts from seven commonly cultivated plants for their nutraceutical potential; ability to inhibit acetylcholinesterase (AChE) and butyryl-cholinesterase (BuChE), and provision of antioxidant activity through their 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging capabilities. Potential neurotoxicity of plant extracts was examined via application to SHSY-5Y neuroblastoma cells and quantitation of cell viability. Methanolic extracts of

Indexed as

Dietary SupplementsPlant LeavesPlants, MedicinalAntioxidantsCell Line, TumorCell SurvivalCholinesterase InhibitorsCytotoxinsDose-Response Relationship, DrugHumansMolecular Docking SimulationNeurodegenerative DiseasesNeuroprotective AgentsPhytochemicalsPlant ExtractsAntioxidantsCholinesterase InhibitorsCytotoxinsNeuroprotective AgentsPhytochemicalsPlant Extractsacetylcholinesterase inhibitorsAlzheimer diseaseantioxidantsbutyrylcholinesterase inhibitorsmolecular modellingnutraceuticalsphytochemicals

Identifiers

PMID33203123
PMCPMC7698063
OpenAlexW3100601105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.