Evidence map›Paper›PMID 33202936›Full record

ReviewCancers2020

Colon Capsule Endoscopy vs. CT Colonography Following Incomplete Colonoscopy: A Systematic Review with Meta-Analysis.

Ulrik Deding, Lasse Kaalby, Henrik Bøggild, Eva Plantener, Mie Kruse Wollesen, Morten Kobaek-Larsen, Siri Juul Hansen, Gunnar Baatrup

Abstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Strategies to manage the difficult colonoscopy.World journal of gastrointestinal endoscopy · 2023
    Review
  11. Article
  12. Advances in colon capsule endoscopy: a review of current applications and challenges.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ulrik DedingDepartment of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.ORCID 0000-0002-8263-2989
Lasse KaalbyDepartment of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.ORCID 0000-0002-6721-3604
Henrik BøggildPublic Health and Epidemiology Group, Department of Health Science and Technology, Aalborg University, 9220 Aalborg Ø, Denmark.ORCID 0000-0001-8934-5002
Eva PlantenerDepartment of Surgery, Odense University Hospital, 5000 Odense C, Denmark.
Mie Kruse WollesenDepartment of Surgery, Odense University Hospital, 5000 Odense C, Denmark.
Morten Kobaek-LarsenDepartment of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.ORCID 0000-0002-5097-9283
Siri Juul HansenDepartment of Surgery, Odense University Hospital, 5000 Odense C, Denmark.
Gunnar BaatrupDepartment of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.

Funding

The Danish Cancer Society R100-A6747
6 · The paper itself

Abstract

Following incomplete colonoscopy (IC) patients often undergo computed tomography colonography (CTC), but colon capsule endoscopy (CCE) may be an alternative. We compared the completion rate, sensitivity and diagnostic yield for polyp detection from CCE and CTC following IC. A systematic literature search resulted in twenty-six studies. Extracted data included inter alia, complete/incomplete investigations and polyp findings. Pooled estimates of completion rates of CCE and CTC and complete colonic view rates (CCE reaching the most proximal point of IC) of CCE were calculated. Per patient diagnostic yields of CCE and CTC were calculated stratified by polyp sizes. CCE completion rate and complete colonic view rate were 76% (CI 95% 68-84%) and 90% (CI 95% 83-95%). CTC completion rate was 98% (CI 95% 96-100%). Diagnostic yields of CTC and CCE were 10% (CI 95% 7-15%) and 37% (CI 95% 30-43%) for any size, 13% (CI 95% 9-18%) and 21% (CI 95% 12-32%) for >5-mm and 4% (CI 95% 2-7%) and 9% (CI 95% 3-17%) for >9-mm polyps. No study performed a reference standard follow-up after CCE/CTC in individuals without findings, rendering sensitivity calculations unfeasible. The increased diagnostic yield of CCE could outweigh its slightly lower complete colonic view rate compared to the superior CTC completion rate. Hence, CCE following IC appears feasible for an introduction to clinical practice. Therefore, randomized studies investigating CCE and/or CTC following incomplete colonoscopy with a golden standard reference for the entire population enabling estimates for sensitivity and specificity are needed.

Indexed as

colon cancercolon capsule endoscopycolonoscopycolorectal cancercomputed tomography colonographyCT colonographyincomplete investigationmeta-analysispolypssystematic review

Identifiers

PMID33202936
PMCPMC7697096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.