Evidence map›Paper›PMID 33202918›Full record

ArticleMolecules (Basel, Switzerland)2020

In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements.

Lili Qin, Tianfeng Lu, Yao Qin, Yiwei He, Ningxin Cui, Ai Du, Jingyu Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Could nanotechnology improve exercise performance? Evidence from animal studies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lili QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Tianfeng LuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Yao QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Yiwei HeSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Ningxin CuiSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Ai DuSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0002-6113-6185
Jingyu SunSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Tongji University · CN

Funding

National Natural Science Foundation of China 31771313
6 · The paper itself

Abstract

Resveratrol (RSV) is a natural flavonoid polyphenol compound extracted from the plants which shows various biological activities. However, the clinical application of RSV is limited by its poor aqueous solubility, rapid metabolism and poor bioavailability. In this study, resveratrol-loaded solid lipid nanoparticles (RSV- SLNs) was design as a nano-antioxidant against the physical fatigue. The resultant RSV-SLNs were characterized by photon correlation spectroscopy (PCS), transmission electron micrographs (TEM), zeta potential, differential scanning calorimetry (DSC) and Raman spectroscopy pattern. Furthermore, the in vivo anti-fatigue effect assays showed that RSV-SLNs prolonged the mice exhausted time and running distance. The biochemical parameters of blood related to fatigue suggested that RSV-SLNs have potential applications to improve the antioxidant defense of the mice after extensive exercise and confer anti-fatigue capability. Furthermore, the molecular mechanisms of antioxidant by RSV-SLNs supplementation was investigated through the analysis of silent information regulator 2 homolog 1 (SIRT1) protein expression, which demonstrated that it could downregulate the expression of SIRT1 and increase autophagy markers, microtubule-associated protein 1 light chain 3-II (LC3-II) and sequestosome-1 (SQSTM1/p62). These results reveal that the RSV-SLNs may have great potential used as a novel anti-fatigue sports nutritional supplement.

Indexed as

Dietary SupplementsPhysical Conditioning, AnimalAnimalsAntioxidantsBiological AvailabilityCalorimetry, Differential ScanningDrug CarriersFatigueLipid PeroxidationLipidsMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsNanoparticlesAntioxidantsDrug CarriersLipidsMap1lc3b protein, mouseMicrotubule-Associated ProteinsResveratrolSequestosome-1 ProteinSirt1 protein, mouseSirtuin 1Sqstm1 protein, mouseanti-fatiguedrug deliverynutrition supplementsresveratrolsolid lipid nanoparticles (SLNs)

Identifiers

PMID33202918
PMCPMC7696174
OpenAlexW3098849840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.