Evidence map›Paper›PMID 33202862›Full record

ArticleInternational journal of molecular sciences2020

Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli.

Donghyun Nam, Aran Park, Maria Jose Dubon, Jinyeong Yu, Wootak Kim, Youngsook Son, Ki-Sook Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Donghyun NamDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Aran ParkGraduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Maria Jose DubonGraduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Jinyeong YuGraduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Wootak KimDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Youngsook SonGraduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.
Ki-Sook ParkDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Kyung Hee University · KR

Funding

National Research Foundation of Korea 2015R1D1A1A09057839National Research Foundation of Korea 2017M3A9E4065331
6 · The paper itself

Abstract

Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or interact with each other during BM-MSC mobilization. This study used mouse bone marrow-derived mesenchymal stem cell-like ST2 cells and human BM-MSCs to evaluate whether SP, TGF-β, and SDF-1 mutually regulate their respective effects on the mobilization of BM-MSCs. SP pretreatment of ST2 and BM-MSCs impaired their response to TGF-β while the introduction of SP receptor antagonist restored the mobilization of ST2 and BM-MSCs in response to TGF-β. TGF-β pretreatment did not affect the migration of ST2 and BM-MSCs in response to SP, but downregulated their migration in response to SDF-1. SP pretreatment modulated the activation of TGF-β noncanonical pathways in ST2 cells and BM-MSCs, but not canonical pathways. These results suggest that the migration of mesenchymal stem cells is regulated by complex functional interactions between SP, TGF-β, and SDF-1. Thus, understanding the complex functional interactions of these chemotactic stimuli would contribute to ensuring the development of safe and effective combination treatments for the mobilization of BM-MSCs.

Indexed as

AnimalsBone Marrow CellsCell LineChemokine CXCL12ChemotaxisHumansMesenchymal Stem CellsMiceSignal TransductionTransforming Growth Factor betaChemokine CXCL12CXCL12 protein, humanCxcl12 protein, mouseTransforming Growth Factor betamesenchymal stem cellmigrationSDF-1substance PTGF-β

Identifiers

PMID33202862
PMCPMC7696304
OpenAlexW3098997386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.