Evidence map›Paper›PMID 33202842›Full record

ReviewCancers2020

Cold Atmospheric Plasma: A Promising Controller of Cancer Cell States.

Xiaofeng Dai, Kateryna Bazaka, Erik W Thompson, Kostya Ken Ostrikov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  6. [Effects of cold atmosphere plasma treatment on the biological behavior of human gingival fibroblasts].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Xiaofeng DaiHospital of Xi'an Jiaotong University, Xi'an 710061, China.
Kateryna BazakaResearch School of Electrical, Energy and Materials Engineering, College of Engineering and Computer Science, The Australian National University, Canberra, ACT 2600, Australia.ORCID 0000-0003-2032-6377
Erik W ThompsonInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.ORCID 0000-0002-9723-4924
Kostya Ken OstrikovInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Australian National University · AUJiangnan University · CNQueensland University of Technology · AUTranslational Research Institute · AU

Funding

Fundamental Research Funds for the Central Universities JUSRP22011National Natural Science Foundation of China 81972789National Science and Technology Major project 2018ZX10302205-004-002
6 · The paper itself

Abstract

Rich in reactive oxygen and nitrogen species, cold atmospheric plasma has been shown to effectively control events critical to cancer progression; selectively inducing apoptosis, reducing tumor volume and vasculature, and halting metastasis by taking advantage of, e.g., synergies between hydrogen peroxide and nitrites. This paper discusses the efficacy, safety and administration of cold atmospheric plasma treatment as a potential tool against cancers, with a focus on the mechanisms by which cold atmospheric plasma may affect critical transitional switches that govern tumorigenesis: the life/death control, tumor angiogenesis and epithelial-mesenchymal transition, and drug sensitivity spectrum. We introduce the possibility of modeling cell transitions between the normal and cancerous states using cold atmospheric plasma as a novel research avenue to enhance our understanding of plasma-aided control of oncogenesis.

Indexed as

cancer state transitioncold atmospheric plasmaoncotherapyreactive species

Identifiers

PMID33202842
PMCPMC7696697
OpenAlexW3102335347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.