Evidence map›Paper›PMID 33202574›Full record

ArticleJournal of clinical medicine2020

Handwriting Analysis in Children and Adolescents with Hemophilia: A Pilot Study.

Gianluigi Pasta, Maria Elisa Mancuso, Filomena De Felice, Alexander Seuser, Salvatore Annunziata, Flora Peyvandi, Elena Santagostino, Mario Mosconi, Axel Seuser

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gianluigi PastaOperative Unit of Orthopedics and Traumatology, Department of Clinical-Surgical Sciences, Diagnostics and Pediatrics, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-1919-5130
Maria Elisa MancusoFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, 20122 Milan, Italy.
Filomena De FeliceFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, 20122 Milan, Italy.
Alexander SeuserKlinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätklinikum, 53127 Bonn, Germany.
Salvatore AnnunziataOperative Unit of Orthopedics and Traumatology, Department of Clinical-Surgical Sciences, Diagnostics and Pediatrics, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0003-3850-2156
Flora PeyvandiFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, 20122 Milan, Italy.
Elena SantagostinoFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, 20122 Milan, Italy.
Mario MosconiOperative Unit of Orthopedics and Traumatology, Department of Clinical-Surgical Sciences, Diagnostics and Pediatrics, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Axel SeuserPraxis für Prävention, Rehabilitation und Orthopädie, 53225 Bonn, Germany.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITPoliclinico San Matteo Fondazione · ITOrthopädische Praxis · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHandwriting is a complex task that requires the integrity of different sensorimotor components to be performed successfully. Patients with hemophilia suffer from recurrent joint bleeds that may occur in the elbow, causing elbow dysfunction with handwriting performance impairment. In our study, we described instrumental dysgraphia that is related to functional disturbances. This pilot study aims to evaluate the handwriting performance in a group of patients with hemophilia.

methodsThe study was performed at the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center in Milan. Boys with severe and moderate hemophilia A and B regularly followed-up at that Center, with age between 6-19 years, were eligible. Patients were invited to the Center for one multidisciplinary evaluation of the upper limbs that included: Clinical examination, surface electromyography, and handwriting assessment.

resultsAll patients, but one, completed handwriting assessment. Overall, 14/19 (74%) had abnormal handwriting, which was overt instrumental dysgraphia in six (32%). There was no difference in Hemophilia Joint Health Score (HJHS) between dysgraphic and non-dysgraphic boys, while surface electromyography (sEMG) revealed a prevalence of flexor muscles of the upper limb in dysgraphic as compared with non-dysgraphic boys.

conclusionsThe rather high prevalence of instrumental dysgraphia found in this pilot study deserves a further development of this preliminary experience by increasing the number of examined patients and comparing them with a control group, including quality of life and psychological assessment.

Indexed as

handwritinghemophiliaHJHSsEMGupper limb

Identifiers

PMID33202574
PMCPMC7697872
OpenAlexW3100872142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.