ArticlePharmaceuticals (Basel, Switzerland)2020
Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury.
Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.PloS one · 2026Article
- Anesthetic Management of Brain-Dead Donors During Organ Retrieval: Hemodynamic Effects and Potential Organ-Protective Implications - A Retrospective Analysis of 85 Cases.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Opioids and the kidney: two sides of the same coin.Frontiers in pharmacology · 2024Review
- Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Intestinal Ischemia/Reperfusion Injury.Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Progression to renal damage by ischemia-reperfusion injury (IRI) is the result of the dysregulation of various tissue damage repair mechanisms. Anesthetic preconditioning with opioids has been shown to be beneficial in myocardial IRI models. Our main objective was to analyze the influence of pharmacological preconditioning with opioids in renal function and expression of molecules involved in tissue repair and angiogenesis. Experimental protocol includes male rats with 45 min ischemia occluding the left renal hilum followed by 24 h of reperfusion with or without 60 min preconditioning with morphine/fentanyl. We analyzed serum creatinine and renal
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Registered trials
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