Evidence map›Paper›PMID 33202379›Full record

ArticleAging2020

Glycemic traits and Alzheimer's disease: a Mendelian randomization study.

Yuesong Pan, Weiqi Chen, Hongyi Yan, Mengxing Wang, Xianglong Xiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Higher fasting brain glucose is associated with lower gray matter volume in healthy adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
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  13. Mendelian randomization study of diabetes and dementia in the Million Veteran Program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
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  19. Diabetes and dementia: Clinical perspective, innovation, knowledge gaps.Journal of diabetes and its complications · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yuesong PanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Weiqi ChenDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hongyi YanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Mengxing WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xianglong XiangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNNational Clinical Research Center for Digestive Diseases · CNBeijing Tian Tan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous observational studies have reported an association between impaired glucose metabolism and Alzheimer's disease. This study aimed to examine the causal association of glycemic traits with Alzheimer's disease. We used a two-sample Mendelian randomization approach to evaluate the causal effect of six glycemic traits (type 2 diabetes, fasting glucose, fasting insulin, hemoglobin A1c, homeostasis model assessment- insulin resistance and HOMA-β-cell function) on Alzheimer's disease. Summary data on the association of single nucleotide polymorphisms with these glycemic traits were obtained from genome-wide association studies of the DIAbetes Genetics Replication And Meta-analysis and Meta-Analyses of Glucose and Insulin-related traits Consortium. Summary data on the association of single nucleotide polymorphisms with Alzheimer's disease were obtained from the International Genomics of Alzheimer's Project. The Mendelian randomization analysis showed that 1-standard deviation higher fasting glucose and lower HOMA-β-cell function (indicating pancreatic β-cell dysfunction) were causally associated with a substantial increase in risk of Alzheimer's disease (odds ratio=1.33, 95% confidence interval: 1.04-1.68, p=0.02; odds ratio=1.92, 95% confidence interval: 1.15-3.21, p=0.01). However, no significant association was observed for other glycemic traits. This Mendelian randomization analysis provides evidence of causal associations between glycemic traits, especially high fasting glucose and pancreatic β-cell dysfunction, and high risk of Alzheimer's disease.

Indexed as

Polymorphism, Single NucleotideAlzheimer DiseaseBiomarkersBlood GlucoseDatabases, GeneticDiabetes Mellitus, Type 2Genome-Wide Association StudyGlycated HemoglobinHumansInsulinInsulin ResistanceInsulin-Secreting CellsMendelian Randomization AnalysisRisk AssessmentRisk FactorsBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanInsulinAlzheimer’s diseasediabetesglycemic traitsinsulin resistanceMendelian randomization

Identifiers

PMID33202379
PMCPMC7746331
OpenAlexW3103755232

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.