ArticleRadiology2021
Mean Apparent Diffusion Coefficient Is a Sufficient Conventional Diffusion-weighted MRI Metric to Improve Breast MRI Diagnostic Performance: Results from the ECOG-ACRIN Cancer Research Group A6702 Diffusion Imaging Trial.
Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02022579 (A Multi-Center Study Evaluating the Utility of Diffusion Weighted Imaging for Detection and Diagnosis of Breast Cancer), which is not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Center Study Evaluating the Utility of Diffusion Weighted Imaging for Detection and Diagnosis of Breast Cancer
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Establishing an Evidence-based Modern Breast MRI Program.Journal of breast imaging · 2026Review
- Reducing breast biopsy at MRI: comparison of minimum ADC cutoff and mean ADC cutoff identified by the ECOG-ACRIN A6702 multicenter trial.BMC cancer · 2025Article
- Evaluating Breast Cancer Intravoxel Incoherent Motion MRI Biomarkers across Software Platforms.Radiology. Imaging cancer · 2025Article
- Improved diagnostic value of whole-lesion histogram and texture analyses on multiparametric breast MRI for papillary neoplasms with non-mass enhancement.Gland surgery · 2025Article
- Quantitative [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Histogram analysis of diffusion-weighted imaging with a fractional order calculus model in breast cancer: diagnostic performance and associations with prognostic factors.Frontiers in radiology · 2025Article
- Non-contrast Breast MR Imaging.Radiologic clinics of North America · 2024Review
- Added value of the EUSOBI diffusion levels in breast MRI.European radiology · 2024Article
- Quantitative characterization of breast lesions and normal fibroglandular tissue using compartmentalized diffusion-weighted model: comparison of intravoxel incoherent motion and restriction spectrum imaging.Breast cancer research : BCR · 2024Article
- Update on DWI for Breast Cancer Diagnosis and Treatment Monitoring.AJR. American journal of roentgenology · 2024Review
- Diffusion weighted imaging for improving the diagnostic performance of screening breast MRI: impact of apparent diffusion coefficient quantitation methods and cutoffs.Frontiers in oncology · 2024Article
- Breast Multiparametric MRI for Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer: The BMMR2 Challenge.Radiology. Imaging cancer · 2024Article
- Relaxation-Diffusion Spectrum Imaging for Probing Tissue Microarchitecture.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023Article
- Quantitative apparent diffusion coefficient metrics for MRI-only suspicious breast lesions: any added clinical value?Quantitative imaging in medicine and surgery · 2023Article
- Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database.European radiology · 2023Article
- Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding.BMC medical imaging · 2022Article
- Article
- Implementation of Whole-Body MRI (MY-RADS) within the OPTIMUM/MUKnine multi-centre clinical trial for patients with myeloma.Insights into imaging · 2022Article
- Article
- Challenges in ensuring the generalizability of image quantitation methods for MRI.Medical physics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 11 institutions in 1 country.
Elizabeth S McDonaldFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).
Justin RomanoffFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-7058-9621
Habib RahbarFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0003-4835-1478
Averi E KitschFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).
Sara M HarveyFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-0460-7841
Jennifer G WhisenantFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-3435-2464
Thomas E YankeelovFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-6201-3913
Linda MoyFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-9564-9360
Wendy B DeMartiniFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-5600-6626
Basak E DoganFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-7024-093X
Wei T YangFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0003-2936-2972
Lilian C WangFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-4221-8791
Bonnie N JoeFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-9333-1463
Lisa J WilmesFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).
Nola M HyltonFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-6747-1662
Karen Y OhFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-8399-1767
Luminita A TudoricaFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-4904-7358
Colleen H NealFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0002-4041-8394
Dariya I MalyarenkoFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0003-0403-1501
Christopher E ComstockFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).
Mitchell D SchnallFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-9646-945X
Thomas L ChenevertFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).
Savannah C PartridgeFrom the Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (E.S.M., M.D.S.); Center for Statistical Sciences, Brown University, Providence, RI (J.R.); Department of Radiology, University of Washington, 1144 Eastlake Ave E, LG2-200, Seattle, WA 98109 (H.R., A.E.K., S.C.P.); Departments of Radiology and Radiological Sciences (S.M.H.) and Medicine (J.G.W.), Vanderbilt University Medical Center, Nashville, Tenn; Vanderbilt-Ingram Cancer Center, Nashville, Tenn (J.G.W.); Department of Biomedical Engineering, University of Texas, Austin, Tex (T.E.Y.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (W.B.D.); Department of Diagnostic Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (B.E.D.); Department of Breast Imaging, MD Anderson Cancer Center, Houston, Tex (W.T.Y.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.C.W.); Department of Radiology and Biomedical Imaging, University of California, San Francisco School of Medicine, San Francisco, Calif (B.N.J., L.J.W., N.M.H.); Department of Radiology, Oregon Health and Science University, Portland, Ore (K.Y.O., L.A.T.); Department of Radiology/MRI, University of Michigan, Ann Arbor, Mich (C.H.N., D.I.M., T.L.C.); and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (C.E.C.).ORCID 0000-0001-6370-9111
University of Pennsylvania · USUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of Washington · USOregon Health & Science University · USBrown University · USMemorial Sloan Kettering Cancer Center · USNew York University · USNorthwestern University · USThe University of Texas MD Anderson Cancer Center · USVanderbilt University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MARRA - ADOPT New Technologies for RDC/CDMSU01CA080098 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI SCHNALL, MITCHELL D. · 1999 to 2011
$182.7MProject-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6MStatistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO · 2014 to 2026
$111.2MBIOSTATISTICS DATA MANAGEMENT CENTER FOR ACROINU01CA079778 · NCI · BROWN UNIVERSITY · PI GATSONIS, CONSTANTINE A. · 1999 to 2011
$48.6MUT MD Anderson Cancer Center Network Lead Academic Participating Site (LAP) UG1UG1CA233329 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KELLY K HUNT, CHELSEA Camille PINNIX · 2019 to 2026
$11.1MNetwork Lead Academic Participating Site: Memorial Sloan Kettering Cancer CenterUG1CA233290 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAROL AGHAJANIAN, Darren Feldman · 2019 to 2026
$10.2MUT Southwestern NCI National Clinical Trials Network (NCTN) LAPS - Supplemental Funds YR4UG1CA233302 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI David Eric Gerber · 2019 to 2026
$6.4MNorthwestern University Lead Academic Participating Site Supplement Year 2UG1CA233320 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BENSON, AL B, MATEI, DANIELA E · 2019 to 2025
$5.5MUM LAPs -UG1 GrantUG1CA233160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANNE F SCHOTT · 2019 to 2026
$5.4MNational Clinical Trials Network Research at the University of WisconsinUG1CA233277 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Lisa M Barroilhet, Andrew M. Baschnagel · 2019 to 2026
$4.9MQuantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA203883NCI NIH HHS R01 CA207290NCI NIH HHS U01 CA079778NCI NIH HHS U01 CA080098NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA166104NCI NIH HHS U01 CA225427NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180820NCI NIH HHS UG1 CA233160NCI NIH HHS UG1 CA233270NCI NIH HHS UG1 CA233277NCI NIH HHS UG1 CA233290NCI NIH HHS UG1 CA233302NCI NIH HHS UG1 CA233320NCI NIH HHS UG1 CA233328NCI NIH HHS UG1 CA233329
Abstract
Background The Eastern Cooperative Oncology Group and American College of Radiology Imaging Network Cancer Research Group A6702 multicenter trial helped confirm the potential of diffusion-weighted MRI for improving differential diagnosis of suspicious breast abnormalities and reducing unnecessary biopsies. A prespecified secondary objective was to explore the relative value of different approaches for quantitative assessment of lesions at diffusion-weighted MRI. Purpose To determine whether alternate calculations of apparent diffusion coefficient (ADC) can help further improve diagnostic performance versus mean ADC values alone for analysis of suspicious breast lesions at MRI. Materials and Methods This prospective trial (ClinicalTrials.gov identifier: NCT02022579) enrolled consecutive women (from March 2014 to April 2015) with a Breast Imaging Reporting and Data System category of 3, 4, or 5 at breast MRI. All study participants underwent standardized diffusion-weighted MRI (
Indexed as
AdultAgedBreastBreast NeoplasmsDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleHumansMiddle AgedProspective StudiesReproducibility of ResultsSensitivity and SpecificitySocieties, MedicalYoung Adult
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02022579ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.