Evidence map›Paper›PMID 33201518›Full record

SynthesisAnaesthesia2021

PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations.

N Aldamluji, A Burgess, E Pogatzki-Zahn, J Raeder, H Beloeil, PROSPECT Working Group collaborators*

4 registry-linked trialsOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 62 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 7 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05435833 nacompletednot on this mapstarted 2022, after this paper: background citation

Ultrasound-Guided Submandibular Parapharyngeal Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief in Adults. A Prospective Randomized Study

TypeinterventionalSponsorTanta UniversityRan2022 to 2023Enrolled50ConditionsAnalgesiaArmsbilateral ultrasound guided GPN block
NCT05928520 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of Analgesic Efficacy of Topical Tramadol Versus Topical Lidocaine in the Control of Post Operative Pain in Children After Tonsillectomy

TypeinterventionalSponsorAl-Azhar UniversityRan2023 to 2024Enrolled80ConditionsPain ManagementArmsTramadol 5%, Lidocaine 2%
NCT06275698 narecruitingnot on this mapstarted 2023, after this paper: background citation

HONEY for the Treatment of POst-Tonsillectomy Pain - a Double-blind, Randomised, Placebo Controlled, Single Site Trial

TypeinterventionalSponsorEast and North Hertfordshire NHS TrustRan2023 to 2027Enrolled100ConditionsPost Surgical Pain, AnalgesiaArmsManuka honey MGO 1000, Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring
NCT07370129 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Impact of Transnasal Sphenopalatine Ganglion Block on Pain Relief and Recovery Following Tonsillectomy

TypeinterventionalSponsorAnkara UniversityRan2025 to 2026Enrolled28ConditionsPost Tonsillectomy Pain, Post Operative Analgesia, Opioid Consumption, Sphenopalatine Ganglion BlockArmsTransnasal Transmucosal Sphenopalatine Ganglion Block, Lidocaine %5, Saline (0.9% NaCl)
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 7 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. [Clinical practice guideline for perioperative pain management in pediatric low-temperature plasma tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Guideline
  2. The role of postoperative sucralfate in adults following tonsillectomy and sleep surgery: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  3. Nebulized tranexamic acid for treatment of post-tonsillectomy bleeding: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Perioperative clinical practice recommendations for pediatric tonsillectomy: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
    Pooled it
  8. Trial
  9. Efficacy of Platelet-Rich Plasma in Post-Tonsillectomy Wound Healing and Pain Management: A Randomized Controlled Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Incidence and causes of unplanned acute care revisits after pediatric tonsillectomy with or without adenoidectomy: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  17. [Ultrasound glossopharyngeal block for oropharyngeal pain management in cancer patients].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Observational
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

N AldamlujiDepartment of Adult Anaesthesiology, Sidra Medicine, Qatar.
A BurgessDepartment of Otolaryngology Head and Neck Surgery, Com Maillot-Hartmann Private Hospital, Neuilly sur Seine, France.
E Pogatzki-ZahnDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany.
J RaederDepartment of Anaesthesiology, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway.
H BeloeilDepartment of Anaesthesiology and Critical Care, Université Rennes, Rennes, France.
PROSPECT Working Group collaborators*
Clinique Hartmann · FRUniversité Rennes 2 · FRUniversity Hospital Münster · DEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tonsillectomy is one of the most frequently performed surgical procedures; however, pain management remains challenging. Procedure-specific efficacy as well as specific risks of treatment options should guide selection of pain management protocols based on evidence and should optimise analgesia without harm. The aims of this systematic review were to evaluate the available literature and develop recommendations for optimal pain management after tonsillectomy. A systematic review utilising preferred reporting items for systematic reviews and meta-analysis guidelines with procedure-specific postoperative pain management (PROSPECT) methodology was undertaken. Randomised controlled trials published in the English language up to November 2019 assessing postoperative pain using analgesic, anaesthetic or surgical interventions were identified. Out of the 719 potentially eligible studies identified, 226 randomised controlled trials met the inclusion criteria, excluding the studies examining surgical techniques. Pre-operative and intra-operative interventions that improved postoperative pain were paracetamol; non-steroidal anti-inflammatory drugs; intravenous dexamethasone; ketamine (only assessed in children); gabapentinoids; dexmedetomidine; honey; and acupuncture. Inconsistent evidence was found for local anaesthetic infiltration; antibiotics; and magnesium sulphate. Limited evidence was found for clonidine. The analgesic regimen for tonsillectomy should include paracetamol; non-steroidal anti-inflammatory drugs; and intravenous dexamethasone, with opioids as rescue analgesics. Analgesic adjuncts such as intra-operative and postoperative acupuncture as well as postoperative honey are also recommended. Ketamine (only for children); dexmedetomidine; or gabapentinoids may be considered when some of the first-line analgesics are contra-indicated. Further randomised controlled trials are required to define risk and combination of drugs most effective for postoperative pain relief after tonsillectomy.

Indexed as

TonsillectomyAcupunctureAnalgesiaAnalgesicsAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalChildHoneyHumansPain ManagementPostoperative PainPractice Guidelines as TopicAnalgesicsAnesthetics, LocalAnti-Inflammatory Agents, Non-Steroidalanalgesiaevidence-based medicinepainsystematic reviewtonsillectomy

Identifiers

PMID33201518
PMCPMC8247026
OpenAlexW3105972370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.