Evidence map›Paper›PMID 33201495›Full record

ArticleSpine deformity2021

Risk factors for gastrointestinal complications after spinal fusion in children with cerebral palsy.

Bram P Verhofste, Jay G Berry, Patricia E Miller, Charis N Crofton, Brigid M Garrity, Nicholas D Fletcher, Michelle C Marks, Suken A Shah, Peter O Newton, Amer F Samdani and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Spine deformity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Preoperative Evaluation of the Child With Cerebral Palsy.Journal of the Pediatric Orthopaedic Society of North America · 2026
    Review
  3. Article
  4. Article
  5. The machine-vision image guided surgery system reduces fluoroscopy time, ionizing radiation and intraoperative blood loss in posterior spinal fusion for scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  6. Incidence, clinical features, and risk factors for acute pancreatitis following posterior instrumented fusion surgery for lumbar degenerative disease: a single-center, retrospective analysis of 20,929 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Bram P VerhofsteDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8517-7195
Jay G BerryDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Patricia E MillerDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0141-717X
Charis N CroftonDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Brigid M GarrityDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Nicholas D FletcherDepartment of Orthopaedic Surgery, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Michelle C MarksSetting Scoliosis Straight Foundation, San Diego, CA, USA.
Suken A ShahDepartment of Orthopaedic Surgery, A. I. DuPont Institute, Wilmington, DE, USA.
Peter O NewtonDepartment of Orthopaedic Surgery, UC San Diego University of California, San Diego, CA, USA.ORCID 0000-0001-9437-7973
Amer F SamdaniDepartment of Orthopaedic Surgery, Shriner's Hospital for Children, Philadelphia, PA, USA.ORCID 0000-0002-4206-610X
Mark F AbelDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-7869-2172
Paul D SponsellerDepartment of Orthopaedic Surgery, John Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0003-2934-6374
Harms Study Group
Michael P GlotzbeckerDepartment of Orthopaedic Surgery, University Hospital Cleveland Medical Center, Rainbow Babies and Children's Hospital, 201 Adelbert Road, Cleveland, OH, 44106, USA. Michael.Glotzbecker@UHhospitals.org.ORCID 0000-0003-0310-4481
Boston Children's Hospital · USDuPont (United States) · USJohns Hopkins Hospital · USRainbow Babies & Children's Hospital · USSetting Scoliosis Straight Foundation · USUniversity of California San Diego · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

designProspective cerebral palsy (CP) registry review.

objectives(1) Evaluate the incidence/risk factors of gastrointestinal (GI) complications in CP patients after spinal fusion (SF); and (2) investigate the validity of the modified Clavien-Dindo-Sink classification.

backgroundPerioperative GI complications result in increased length of stay (LOS) and patient morbidity/mortality. However, none have analyzed the outcomes of GI complications using an objective classification system.

methodsA prospective/multicenter CP database identified 425 children (mean, 14.4 ± 2.9 years; range, 7.9-21 years) who underwent SF. GI complications were categorized using the modified Clavien-Dindo-Sink classification. Grades I-II were minor complications and grades III-V major. Patients with and without GI complications were compared.

results87 GI complications developed in 69 patients (16.2%): 39 minor (57%) and 30 major (43%). Most common were pancreatitis (n = 45) and ileus (n = 22). Patients with preoperative G-tubes had 2.2 × odds of developing a GI complication compared to oral-only feeders (OR 2.2; 95% CI 0.98-4.78; p = 0.006). Similarly, combined G-tube/oral feeders had 6.7 × odds compared to oral-only (OR 6.7; 95% CI 3.10-14.66; p < 0.001). The likelihood of developing a GI complication was 3.4 × with normalized estimated blood loss (nEBL) ≥ 3 ml/kg/level fused (OR 3.41; 95% CI 1.95-5.95; p < 0.001). Patients with GI complications had more fundoplications (29% vs. 17%; p = 0.03) and longer G-tube fasting periods (3 days vs. 2 days; p < 0.001), oral fasting periods (5 days vs. 2 days; p < 0.001), ICU admissions (6 days vs. 3 days; p = 0.002), and LOS (15 days vs. 8 days; p < 0.001). LOS correlated with the Clavien-Dino-Sink classification.

conclusionGastrointestinal complications such as pancreatitis and ileus are not uncommon after SF in children with CP. This is the first study to investigate the validity of the modified Clavien-Dindo-Sink classification in GI complications after SF. Our results suggest a correlation between complication severity grade and LOS. The complexity of perioperative enteral nutritional supplementation requires prospective studies dedicated to enteral feeding protocols. LEVEL OF EVIDENCE: Therapeutic-level III.

Indexed as

Cerebral PalsyGastrointestinal DiseasesSpinal FusionChildHumansPostoperative ComplicationsProspective StudiesRisk FactorsCerebral palsyComplicationsGastrointestinal complicationsPediatricScoliosisSpinal fusion

Identifiers

PMID33201495
OpenAlexW3100463297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.