Evidence map›Paper›PMID 33201350›Full record

ArticleMolecular imaging and biology2021

Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats.

David Rey-Bretal, Alexis Moscoso, Noemí Gómez-Lado, Anxo Fernández-Ferreiro, Jesús Silva-Rodríguez, Álvaro Ruibal, Pablo Aguiar

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Deep-learning-derived input function in dynamic [Frontiers in nuclear medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David Rey-BretalMolecular Imaging Group, Department of Radiology, Faculty of Medicine, University of Santiago de Compostela (USC), IDIS, Campus Vida, 15782, Santiago de Compostela, Spain.
Alexis MoscosoNuclear Medicine Department and Molecular Imaging Group, IDIS and University Hospital Santiago de Compostela (CHUS), Travesía da Choupana s/n, 15706, Santiago de Compostela, Spain.
Noemí Gómez-LadoMolecular Imaging Group, Department of Radiology, Faculty of Medicine, University of Santiago de Compostela (USC), IDIS, Campus Vida, 15782, Santiago de Compostela, Spain.
Anxo Fernández-FerreiroPharmacy Department and Pharmacology Group, IDIS and University Hospital CHUS, Travesía da Choupana s/n, 15706, Santiago de Compostela, Spain.
Jesús Silva-RodríguezNuclear Medicine Department and Molecular Imaging Group, IDIS and University Hospital Santiago de Compostela (CHUS), Travesía da Choupana s/n, 15706, Santiago de Compostela, Spain.
Álvaro RuibalMolecular Imaging Group, Department of Radiology, Faculty of Medicine, University of Santiago de Compostela (USC), IDIS, Campus Vida, 15782, Santiago de Compostela, Spain.
Pablo AguiarMolecular Imaging Group, Department of Radiology, Faculty of Medicine, University of Santiago de Compostela (USC), IDIS, Campus Vida, 15782, Santiago de Compostela, Spain. pablo.aguiar.fernandez@sergas.es.ORCID 0000-0002-7322-2195
Universidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time AIFs, but its application in longitudinal studies is still impeded by the cumbersome surgeries and high failure rates. We studied the feasibility and reproducibility of double arterial-venous shunt strategies for conducting longitudinal PET studies with real-time AIFs in rats. PROCEDURES: We studied the feasibility of double arterial-venous shunts in rats in the right/left inguinal region and evaluated inter-animal and intra-animal AIF reproducibilities. Image-derived input function (IDIF) was also obtained for comparison. Dynamic brain FDG PET studies were conducted to estimate kinetic constants and Cerebral Metabolic Rate of Glucose (CMR

resultsWe showed that longitudinal AIFs from double arterial-venous shunts can be obtained with very high success rate of the surgeries (88 %). Our results provided highly reproducible AIF measurements with low inter-animal variabilities (11 %) and intra-animal variabilities (5-10 %) that were included into the kinetic models, such that longitudinal rate constants and CMR

conclusionsWe have demonstrated the feasibility and high reproducibility of conducting longitudinal AIF measurements and consequently accurate kinetic modeling using arterial shunt method.

Indexed as

Cerebrovascular CirculationAnimalsArteriesArteriovenous Shunt, SurgicalBlood GlucoseBrainFeasibility StudiesFluorodeoxyglucose F18KineticsMagnetic Resonance ImagingMaleNeuroimagingPositron-Emission TomographyRatsRats, Sprague-DawleyReproducibility of ResultsBlood GlucoseFluorodeoxyglucose F18Arterial input functionCerebral metabolic glucose rateDynamic PETKinetic modelingPreclinical PET

Identifiers

PMID33201350
OpenAlexW3102977592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.