SynthesisPediatric radiology2021
Practical approach to imaging diagnosis of biliary atresia, Part 1: prenatal ultrasound and magnetic resonance imaging, and postnatal ultrasound.
Synthesis in Pediatric radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Prospective evaluation of the semi-quantitative hepatic subcapsular flow score and hepatic capsular retraction sign in the diagnosis of biliary atresia.European radiology · 2026Article
- A strategy to identify biliary atresia efficiently: A perspective from a Texas center.World journal of pediatric surgery · 2026Review
- Comparison of preoperative serum MMP-7 to liver two-dimensional shear wave elastography and its integration into a novel nomogram for predicting the native liver survival of infants with biliary atresia.Quantitative imaging in medicine and surgery · 2026Article
- Adjunctive value of 3D MRCP in biliary atresia: a retrospective two-center analysis of cholestatic infants.Insights into imaging · 2025Article
- Comprehensive images and serum biomarkers for biliary atresia and other cholestasis in pediatrics.Scientific data · 2025Article
- Diagnostic Scoring in Biliary Atresia.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Transfer learning method for prenatal ultrasound diagnosis of biliary atresia.NPJ digital medicine · 2025Article
- Development of an artificial intelligence-based multimodal diagnostic system for early detection of biliary atresia.BMC medicine · 2025Article
- Ultrasound reliability for biliary atresia diagnoses in children: a single-center study.Qatar medical journal · 2025Article
- Imaging of Benign Biliary Tract Disease.The Indian journal of radiology & imaging · 2024Review
- A case series of prenatal hepatic hilar cyst in the presence of a gallbladder - navigating the dilemma between biliary atresia and choledochal cyst.BMC pediatrics · 2024Article
- Biliary atresia in a 3-month-old infant (case report).Journal of ultrasound · 2024Article
- Simple biliary atresia score-a validated diagnostic aid for infantile cholestasis.Pediatric surgery international · 2024Article
- Diseases of bile duct in children.World journal of gastroenterology · 2024Review
- Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports.Pediatric reports · 2023Article
- Pre- and Immediate Post-Kasai Portoenterostomy Shear Wave Elastography for Predicting Hepatic Fibrosis and Native Liver Outcomes in Patients With Biliary Atresia.Korean journal of radiology · 2023Article
- Anomalies of the fetal gallbladder: pre-and postnatal correlations.Pediatric radiology · 2023Article
- Liver cirrhosis in children - the role of imaging in the diagnostic pathway.Pediatric radiology · 2023Article
- A novel prediction tool based on shear wave elastography, gallbladder ultrasound, and serum biomarkers for the early diagnosis of biliary atresia in infants younger than 60 days old.Quantitative imaging in medicine and surgery · 2023Article
- [Overview of Biliary Atresia].Journal of the Korean Society of Radiology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses towards biliary cirrhosis, end-stage liver failure and death by age 3. Differentiation of biliary atresia from other nonsurgical causes of neonatal cholestasis is challenging because there is no single method for diagnosing biliary atresia, and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis. Concerning imaging, our systematic literature review shows that ultrasonography is the main tool for pre- and neonatal diagnosis. Key prenatal features, when present, are non-visualisation of the gallbladder, cyst in the liver hilum, heterotaxy syndrome and irregular gallbladder walls. Postnatal imaging features have a very high specificity when present, but a variable sensitivity. Triangular cord sign and abnormal gallbladder have the highest sensitivity and specificity. The presence of macro- or microcyst or polysplenia syndrome is highly specific but less sensitive. The diameter of the hepatic artery and hepatic subcapsular flow are less reliable. When present in the context of acholic stools, dilated intrahepatic bile ducts rule out biliary atresia. Importantly, a normal US exam does not rule out biliary atresia. Signs of chronic hepatopathy and portal hypertension (portosystemic derivations such as patent ductus venosus, recanalised umbilical vein, splenomegaly and ascites) should be actively identified for - but are not specific for - biliary atresia.
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