ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021
Vitamin D status and complications, readmissions, and mortality after hip fracture.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Does vitamin D deficiency affect functional outcomes in hip fracture patients? A meta-analysis of cohort studies.Journal of endocrinological investigation · 2024Pooled it
- Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies.Nutrients · 2023Pooled it
- Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.PloS one · 2023Pooled it
- Vitamin D Deficiency in Hip Fracture Patients: Outcome-Specific Associations and Post-Fracture Management-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- 25-Hydroxyvitamin D Levels, Free Serum Calcium, Glomerular Filtration Rate, Albumin, and Femoral Fracture Elderly Patient Mortality.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- The association between levels of vitamin D and clinical outcomes following hip fracture surgery.Irish journal of medical science · 2026Article
- 3-month oral nutritional supplementation adherence impacts positively on survival in malnourished older patients following hip fracture: a real-life study.Frontiers in nutrition · 2026Article
- Vitamin D deficiency is associated with adverse medical outcomes following total shoulder arthroplasty.JSES international · 2025Article
- An exploration of serum 25-hydroxyvitamin D levels after unstable femoral intertrochanteric fractures in community-dwelling elderly.Saudi medical journal · 2025Article
- Preoperative vitamin D deficiency and postoperative delirium risk: multicenter retrospective study.Frontiers in nutrition · 2025Article
- Vitamin D deficiency as a potential risk factor for thyroid cancer: a clinical perspective.Frontiers in nutrition · 2025Article
- Vitamin D deficiency in hip fracture patients is associated with an increased mortality risk.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Increased Early Postoperative Complication Rate after Osteoporotic Hip Fracture in Patients with Low 25 (OH) Vitamin D Levels.Nutrients · 2024Observational
- Review
- A Fracture Liaison Service to Address Vitamin D Deficiency for Patients Hospitalized for Osteoporotic Fracture.Journal of the Endocrine Society · 2024Article
- Article
- Adjuvant Vitamin D Injection in Elderly Patients Before Intertrochanteric Fracture Surgery: A Randomised Controlled Trial.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study.The Journal of clinical endocrinology and metabolism · 2023Article
- Comparing two different orthogeriatric models of care for hip fracture patients: an observational prospective cross-sectional study.BMJ open quality · 2023Observational
- Geriatric nutritional risk index as the prognostic factor in older patients with fragility hip fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low vitamin D in patients with hip fracture is common. In the present study, 407 of 872 (47%) patients had serum calcidiol less than 50 nmol/L. Patients with low vitamin D had more delirium, more new hip fractures, and more medical readmissions, but not more orthopedic complications after 1 year.
introductionWe wanted to study the relation between vitamin D level and postoperative orthopedic and medical complications in patients with hip fracture. In addition, we investigated the effect of giving a single-dose cholecalciferol 100.000 IU.
methodsData were taken from the local hip fracture register. Logistic regression analyses including vitamin D level and potentially confounding variables were performed for complications and readmissions.
resultsA total of 407 (47%) of 872 included hip fractures had low vitamin D at baseline. A total of 155 (18%) developed delirium, and the risk was higher in vitamin D-deficient patients (odds ratio (OR) 1.48, 95% confidence interval (CI) 1.04 to 2.12; p = 0.03). A total of 261 (30%) were readmitted for non-hip-related conditions. Low vitamin D was associated with a higher risk of medical readmissions within 30 days (OR 1.64 (1.03 to 2.61); p = 0.036) and 12 weeks (OR 1.47 (95% CI 1.02 to 2.12); p = 0.039). There was a higher risk of a new hip fracture (OR 2.84 (95% CI 1.15 to 7.03) p = 0.024) in vitamin D-deficient patients. A total of 105 (12%) developed at least one orthopedic complication, with no correlation to baseline vitamin D. Among vitamin D-deficient patients, those receiving a single-dose of 100.000 IU cholecalciferol had fewer orthopedic complications (OR 0.32 (95% CI 0.11 to 0.97) p = 0.044) the first 30 days after surgery.
conclusionLow vitamin D at admission for hip fracture increased the risk of delirium, a new hip fracture, and medical readmissions, but not orthopedic complications. The role of vitamin D supplementation to prevent orthopedic complications requires further study.
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