ArticleJournal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society
Wound Pain and Wound Healing Biomarkers From Wound Exudate: A Scoping Review.
Article in Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effects of non-pharmacological interventions on pain in wound patients during dressing change: A systematic review.Nursing open · 2024Pooled it
- Trial
- Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial.Clinical oral investigations · 2023Trial
- Development, Characterization, and In Vitro Hemostatic Assessment of an Alginate-Based Wound Dressing Incorporating Liposomal Curcumin.Gels (Basel, Switzerland) · 2026Article
- Degradation-as-ignal: a digital-twin framework for disposable optical glucose sensing with lead-free perovskite-inspired films.RSC advances · 2026Article
- Thermal-Inflammatory Index (TI): An Integrated Biomarker of Severity and Prognosis in Chronic Lower-Limb Ulcers.Biomedicines · 2026Article
- Peptide-Based Approaches for Pain Relief and Healing in Wounds.International journal of molecular sciences · 2026Review
- Biomarkers during early healing of extraction procedures: a prospective case series.Clinical oral investigations · 2025Article
- Microfluidic technologies for wearable and implantable biomedical devices.Lab on a chip · 2025Review
- The Impact of Diagnostic Delay on Wound Healing-A Cohort Study in a Primary Care Setting.International wound journal · 2025Article
- Bench to Bedside Evaluation of an Innovative, Non-Bordered Foam Dressing for Use in Exudating Chronic Wounds.International wound journal · 2025Article
- Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study.Biomolecules · 2025Article
- Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.International journal of extreme manufacturing · 2025Review
- Chronic wound management: a liquid diode-based smart bandage with ultrasensitive pH sensing ability.Microsystems & nanoengineering · 2024Article
- Harnessing the Interactions of Wound Exudate Cells with Dressings Biomaterials for the Control and Prognosis of Healing Pathways.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Exploring the effect of wound related pain on psychological stress, inflammatory response, and wound healing.International wound journal · 2024Observational
- Ceramic Dressings-A New Non-Pharmacological Therapeutic Option in the Management of Chronic Wounds?Journal of personalized medicine · 2024Article
- The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.International wound journal · 2023Article
- [Research advances on burn blister fluid].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeEffective management of wound pain is essential for optimal wound healing. Nevertheless, the outcomes of wound pain interventions are based on subjective measures, which can prove problematic in patients with cognitive impairment. Identification of biomarkers associated with wound pain and wound healing can be used to more objectively estimate wound pain and contribute to the development of precise management options to reduce wound pain and promote wound healing. This scoping review aimed to identify wound pain and wound healing biomarkers from wound exudates and to describe different wound collection methods to identify these biomarkers.
methodsWe searched the literature (PROSPERO database registration number: CRD42018103843) via a scoping review. SEARCH STRATEGY: The PubMed database was searched for articles that explored relationships between cutaneous wound pain, wound healing, and biomolecules. Inclusion criteria were articles that reported original data, used adult human samples, and were published in English.
findingsTwenty-one articles were retrieved: 17 investigated molecules from wound exudate associated with wound healing status, and 4 reported molecules associated with wound pain. The most frequently observed wound pain biomarkers were proinflammatory cytokines; the most frequently observed wound healing biomarkers were proteases including those in the matrix metalloproteinase family. Six wound exudate collection methods were identified to extract potential wound pain and wound healing biomarkers from wound exudate. IMPLICATIONS: The results can guide future wound exudate research to validate these wound pain and wound healing biomarkers and to develop therapies targeting these biomarkers to reduce wound pain and promote wound healing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.