ReviewJournal of clinical pathology1987
Value of CD15 immunostaining in diagnosing Hodgkin's disease: a review of published literature.
Review in Journal of clinical pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- Destaining hematoxylin and eosin stains and restaining for immunohistochemistry has diagnostic value for cytology samples.CytoJournal · 2026Article
- Synthesis of LewisCarbohydrate research · 2017Article
- Casual or Causal? Two Unique Cases of Hodgkin's Lymphoma: A Case Report and Literature Review.The American journal of case reports · 2017Review
- Adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance.International journal of obesity (2005) · 2016Article
- Myeloid cells positive for CD10 at invasion front can predict poor outcome in stage II colorectal cancer.International journal of clinical oncology · 2012Article
- Glycoproteomic characterization of carriers of the CD15/Lewisx epitope on Hodgkin's Reed-Sternberg cells.BMC biochemistry · 2011Article
- Multiplexed detection and characterization of rare tumor cells in Hodgkin's lymphoma with multicolor quantum dots.Analytical chemistry · 2010Article
- Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.Cancer cell · 2009Article
- Classical Hodgkin's disease. Clinical impact of the immunophenotype.The American journal of pathology · 1997Article
- Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group.The American journal of pathology · 1997Article
- Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours. Preferential reactivity with malignant tumours.Virchows Archiv : an international journal of pathology · 1996Article
- Comparison of the pattern of expression of Leu-M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy.Histochemistry and cell biology · 1995Article
- The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion.The Histochemical journal · 1992Review
- Expression of CD15 in tumours of the nervous system.The Histochemical journal · 1992Article
- Vimentin expression by Reed-Sternberg cells in Hodgkin's disease.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Paraffin section immunohistochemistry in the diagnosis of Hodgkin's disease and anaplastic large cell (CD30+) lymphomas.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Large cell anaplastic lymphoma: evaluation of immunophenotype on paraffin and frozen sections in comparison with ultrastructural features.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Diffuse lymphocyte-predominant Hodgkin's disease (diffuse paragranuloma). A variant of the B-cell-derived nodular type.The American journal of pathology · 1991Article
- Anti-vimentin antibody reactivity with Reed-Sternberg cells of Hodgkin's disease.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Comparative quality assessment in immunocytochemistry: pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin's disease.Journal of clinical pathology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of antibodies of CD15 as diagnostic markers of Hodgkin's disease was assessed from a review of the literature. A total of 571 cases of Hodgkin's disease and 386 cases of non-Hodgkin's lymphoma were included. The sensitivity of CD15 in detecting cases of Hodgkin's disease was 80% or 91% if cases of lymphocyte predominant Hodgkin's disease were excluded. The specificity of CD15 was only 80.6%, or in other words, 19.4% of cases of non-Hodgkin's lymphoma were CD15 positive. In an ideal test both the sensitivity and specificity would be 100% and if the test performance were no better than chance then they would both be 50%. It is concluded that CD15 immunostaining cannot be regarded as a sensitive or specific marker of Hodgkin's disease. Application of this formal method of analysis to other immunohistological reagents and panels of antibodies is discussed.
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