ArticleChemical reviews2021
Decarboxylative Halogenation of Organic Compounds.
Article in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 257 citations in OpenAlex.
- Article
- Amide synthesis via molecular shuffling of carboxylic acids.Nature communications · 2026Article
- Non-decarboxylative C-H Fluorination of Carboxylic Acids by Iridium Photocatalysis.Organic letters · 2026Article
- Carbocycle editing of ketones proceeds via a radical-mediated bidirectional C-C bond cleavage/coupling strategy.Nature communications · 2026Article
- Regioselective synthesis of 3-halo-2Journal of pesticide science · 2026Article
- Achieving Diverse Functionalizations of Electron-Deficient Aryl Halides via Carbonate-Mediated Electron-Donor-Acceptor Complexes.European journal of organic chemistry · 2026Article
- Dual-Ligand System for Mild Decarbonylative Suzuki-Miyaura Cross-Coupling of Aroyl Chlorides.ACS catalysis · 2026Article
- Chemical staining for fundamental studies and optimization of binders in Li-ion battery negative electrodes.Nature communications · 2026Article
- Article
- Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids.Nature communications · 2026Article
- Synthesis and applications of alkenyl chlorides (vinyl chlorides): a review.Beilstein journal of organic chemistry · 2026Review
- Synthesis and characterization of thermolatent bases with varying activation temperatures.RSC advances · 2025Article
- Article
- Ring-Opening Chlorination and Bromination of Pyrazolopyridines and Isoxazoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Unlocking Chromium Decarboxylative Ligand-to-Metal Charge Transfer: Efficient and Redox-Neutral Allylation of Aldehydes Using Carboxylic Acids.Journal of the American Chemical Society · 2025Article
- Kharasch-Type Haloalkylation of Alkenes by Photoinduced Copper Catalysis.Journal of the American Chemical Society · 2025Article
- Iodo-decarboxylation of Aliphatic Carboxylic Acids with PhI(OAc)Organic letters · 2025Article
- Pd-catalyzed deuteration of aryl halides with deuterium oxide.Nature communications · 2025Article
- Alkene Carboxy-Alkylation via COJournal of the American Chemical Society · 2024Article
- Halodealkenylation: Ozonolysis and Catalytic FeOrganic letters · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decarboxylative halogenation, or halodecarboxylation, represents one of the fundamental key methods for the synthesis of ubiquitous organic halides. The method is based on conversion of carboxylic acids to the corresponding organic halides via selective cleavage of a carbon-carbon bond between the skeleton of the molecule and the carboxylic group and the liberation of carbon dioxide. In this review, we discuss and analyze major approaches for the conversion of alkanoic, alkenoic, acetylenic, and (hetero)aromatic acids to the corresponding alkyl, alkenyl, alkynyl, and (hetero)aryl halides. These methods include the preparation of families of valuable organic iodides, bromides, chlorides, and fluorides. The historic and modern methods for halodecarboxylation reactions are broadly discussed, including analysis of their advantages and drawbacks. We critically address the features, reaction selectivity, substrate scopes, and limitations of the approaches. In the available cases, mechanistic details of the reactions are presented, and the generality and uniqueness of the different mechanistic pathways are highlighted. The challenges, opportunities, and future directions in the field of decarboxylative halogenation are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.