ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2021
The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Tracing the origin of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): A systematic review and narrative synthesis.Journal of medical virology · 2022Pooled it
- Meta-analysis to explain unknown causes of the origins of SARS-COV-2.Environmental research · 2022Pooled it
- Trial
- Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.Microorganisms · 2024Review
- Will COVID-19 become mild, like a cold?Epidemiology and infection · 2024Review
- Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19.The journal of allergy and clinical immunology. In practice · 2023Article
- Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.International journal of biological macromolecules · 2022Article
- SARS-CoV-2 in brief: from virus to prevention.Osong public health and research perspectives · 2022Article
- An updated review of the scientific literature on the origin of SARS-CoV-2.Environmental research · 2022Review
- The origins of COVID-19 pandemic: A brief overview.Transboundary and emerging diseases · 2022Review
- SARS-CoV-2 Omicron: Light at the End of the Long Pandemic Tunnel or Another False Dawn for Immunodeficient Patients?The journal of allergy and clinical immunology. In practice · 2022Article
- Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13.Microbiology spectrum · 2022Article
- There is no "origin" to SARS-CoV-2.Environmental research · 2022Article
- Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus.Future virology · 2022Review
- Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative.Environmental research · 2022Article
- Article
- Genomic Bootstrap Barcodes and Their Application to Study the Evolution of Sarbecoviruses.Viruses · 2022Article
- Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen.bioRxiv : the preprint server for biology · 2022Article
- The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2.Molecular biology and evolution · 2022Review
- Thus spoke peptides: SARS-CoV-2 spike gene evolved in humans and then shortly in rats while the rest of its genome in horseshoe bats and then in treeshrews.Communicative & integrative biology · 2022Article
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2 authors at 2 institutions in 2 countries.
Funding
Abstract
Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2's origin is still controversial. Genomic analyses show SARS-CoV-2 likely to be chimeric, most of its sequence closest to bat CoV RaTG13, whereas its receptor binding domain (RBD) is almost identical to that of a pangolin CoV. Chimeric viruses can arise via natural recombination or human intervention. The furin cleavage site in the spike protein of SARS-CoV-2 confers to the virus the ability to cross species and tissue barriers, but was previously unseen in other SARS-like CoVs. Might genetic manipulations have been performed in order to evaluate pangolins as possible intermediate hosts for bat-derived CoVs that were originally unable to bind to human receptors? Both cleavage site and specific RBD could result from site-directed mutagenesis, a procedure that does not leave a trace. Considering the devastating impact of SARS-CoV-2 and importance of preventing future pandemics, researchers have a responsibility to carry out a thorough analysis of all possible SARS-CoV-2 origins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.