Evidence map›Paper›PMID 33200832›Full record

ArticleThe Laryngoscope2021

Sialographic Analysis of Radioiodine-Associated Chronic Sialadenitis.

Ryan K Thorpe, Megan J Foggia, Kathryn S Marcus, Bruno Policeni, Joan E Maley, Henry T Hoffman

Open access · greenAbstract read
In one paragraph

Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryan K ThorpeDepartment of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.ORCID 0000-0002-8046-407X
Megan J FoggiaDepartment of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
Kathryn S MarcusDepartment of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.ORCID 0000-0003-4284-5792
Bruno PoliceniDepartment of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
Joan E MaleyDepartment of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.
Henry T HoffmanDepartment of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.ORCID 0000-0003-4486-855X
University of Iowa Hospitals and Clinics · US

Funding

Research Training Program in OtolaryngologyT32DC000040 · NIDCD · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R · 1993 to 2025
$5.4M
NIDCD NIH HHS T32 DC000040
6 · The paper itself

Abstract

objectives/hypothesisTo apply a novel sialography classification system to identify parotid and submandibular ductal findings following I-131 therapy and to assess correlates to dose and duration of symptoms. STUDY

designRetrospective single-center case series.

methodsPatients who underwent sialography between February 2008 and February 2019 after previously receiving I-131 treatment were identified via a retrospective chart review. Their sialograms were systematically evaluated and scored by applying the Iowa parotid sialogram scale to also include submandibular gland analysis.

resultsFrom 337 sialograms, 30 (five submandibular, 25 parotid) underwent analysis. Ductal stenosis was identified in all sialograms and was graded as moderate (>50%-75%) in 7/30 cases and severe (>75%) in 15/30 cases. The distal (main) duct was narrowed in 23/30 cases. No association was identified between degree of ductal stenosis and I-131 dose (P = .39), age (P = .81), or time from I-131 therapy to sialogram (P = .97).

conclusionsThe Iowa parotid sialogram scale was successfully applied to report abnormalities of the parotid and submandibular ductal system. The most common manifestation of I-131-associated sialadenitis was a severe stenosis within the distal salivary duct. No statistically significant association was found between degree of ductal stenosis and dose of I-131, age, or duration of symptoms. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E1450-E1456, 2021.

Indexed as

AdultAgedDose-Response Relationship, RadiationFemaleHumansIodine RadioisotopesMaleMiddle AgedParotid DiseasesParotid GlandRadiation InjuriesRadiotherapy DosageRetrospective StudiesSalivary DuctsSialadenitisSialographyIodine-131Iodine Radioisotopesparotid glandradioactive iodinesialadenitisSialographysubmandibular gland

Identifiers

PMID33200832
PMCPMC10049839
OpenAlexW3102803668

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.