Evidence map›Paper›PMID 33200824›Full record

ArticleJournal of medical virology2021

High value of mid-regional proadrenomedullin in COVID-19: A marker of widespread endothelial damage, disease severity, and mortality.

Silvia Spoto, Felice E Agrò, Federica Sambuco, Francesco Travaglino, Emanuele Valeriani, Marta Fogolari, Fabio Mangiacapra, Sebastiano Costantino, Massimo Ciccozzi, Silvia Angeletti

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  19. Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Silvia SpotoDiagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, Italy.ORCID 0000-0002-8799-4997
Felice E AgròIntensive Care and Pain Management, Department of Anesthesia, University Campus Bio-Medico of Rome, Rome, Italy.
Federica SambucoEmergency Department, University Campus Bio-Medico of Rome, Rome, Italy.
Francesco TravaglinoEmergency Department, University Campus Bio-Medico of Rome, Rome, Italy.
Emanuele ValerianiDiagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, Italy.
Marta FogolariUnit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
Fabio MangiacapraUnit of Cardiovascular Science, University Campus Bio-Medico of Rome, Rome, Italy.
Sebastiano CostantinoDiagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, Italy.
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.ORCID 0000-0003-3866-9239
Silvia AngelettiORCID 0000-0002-7393-8732
Università Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widespread endothelial damage due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to a disruption of the adrenomedullin (ADM) system responsible for vascular leakage, increased inflammatory status, and microvascular alteration with multi-organs dysfunction. The aim of this study was to evaluate the role of mid-regional proadrenomedullin (MR-proADM) as a marker of SARS-CoV2 related widespread endothelial damage, clinically identified by organs damage, disease severity and mortality. Patients with SARS-CoV-2 infection has been prospectively enrolled and demographic characteristic, clinical and laboratory data has been evaluated. In the overall population, 58% developed acute respiratory distress syndrome (ARDS), 23.3% of patients died, 6.5% acute cardiac injury, 1.4% of patients developed acute ischemic stroke, 21.2% acute kidney injury, 11.8% acute liver damage, and 5.4% septic shock. The best MR-proADM cut-off values for ARDS development and mortality prediction were 3.04 and 2 nmol/L, respectively. Patients presenting with MR-proADM values ≥2 nmol/L showed a significantly higher mortality risk. In conclusion, MR-proADM values ≥2 nmol/L identify those patients with high mortality risk related to a multiorgan dysfunction syndrome. These patients must be carefully evaluated and considered for an intensive therapeutic approach.

Indexed as

BiomarkersSeverity of Illness IndexAcute Kidney InjuryAcute Lung InjuryAdrenomedullinAgedAged, 80 and overBrain IschemiaComorbidityCOVID-19FemaleHumansMaleMiddle AgedMultiple Organ FailureProtein PrecursorsAdrenomedullinBiomarkersproadrenomedullinProtein Precursorsacute respiratory distress syndromeadrenomedullinCOVID-19multiple organ dysfunction syndromeSARS virus

Identifiers

PMID33200824
PMCPMC7753433
OpenAlexW3106124442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.