Evidence map›Paper›PMID 33200681›Full record

ArticleJournal of biomolecular structure & dynamics2022

Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (m

Vishnu Nayak Badavath, Akhil Kumar, Pralok K Samanta, Siddhartha Maji, Anik Das, Galia Blum, Anjali Jha, Anik Sen

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 52 citations in OpenAlex.

  1. Exploring novel isatin derivatives as SARS-CoV-2 3CLJournal of enzyme inhibition and medicinal chemistry · 2026
    Article
  2. Secondary metabolites fromRSC advances · 2026
    Article
  3. 3CLJournal of computer-aided molecular design · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Journal of molecular structure · 2022
    Article
  10. Article
  11. Identification of Alkaloids fromChemistrySelect · 2022
    Article
  12. Article
  13. Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  14. Isatin derivatives as broad-spectrum antiviral agents: the current landscape.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Vishnu Nayak BadavathInstitute for Drug Research, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-6433-2691
Akhil KumarBiotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.ORCID 0000-0003-4997-9486
Pralok K SamantaSchool of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.ORCID 0000-0002-1926-7720
Siddhartha MajiDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Anik DasDepartment of Chemistry, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India.
Galia BlumInstitute for Drug Research, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-9374-2489
Anjali JhaDepartment of Chemistry, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India.
Anik SenDepartment of Chemistry, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India.ORCID 0000-0002-1336-5995
GITAM University · INHebrew University of Jerusalem · ILBirla Institute of Technology, Mesra · INCentral Institute of Medicinal and Aromatic Plants · INUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19 caused a severe health threat throughout the world. Lack of specific treatments raised an effort to find potential inhibitors for the viral proteins. The recently invented crystal structure of SARS-CoV-2 main protease (M

Indexed as

COVID-19 Drug TreatmentIsatinAntiviral AgentsCoronavirus 3C ProteasesHumansMolecular Docking SimulationMolecular Dynamics SimulationProtease InhibitorsSARS-CoV-2Structure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesIsatinProtease Inhibitorsdensity functional theoryheterocyclic inhibitorsmolecular dockingmolecular dynamicsSARS-CoV-2

Identifiers

PMID33200681
PMCPMC7682386
OpenAlexW3106326031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.