Evidence map›Paper›PMID 33200553›Full record

ArticleCancer medicine2020

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.

Lingling Zhao, Hongliang Liu, Sheng Luo, Patricia G Moorman, Kyle M Walsh, Wei Li, Qingyi Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lingling ZhaoCancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Hongliang LiuDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Patricia G MoormanDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Kyle M WalshDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-5879-9981
Wei LiCancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.ORCID 0000-0002-9479-028X
Qingyi WeiDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-3845-9445
Duke University · USDuke Medical Center · USJilin University · CN

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study)R01CA154823 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 2011 to 2020
$5.7M
NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA154823
6 · The paper itself

Abstract

Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from publically available genome-wide association studies (GWAS) datasets comprising 15,423 individuals of European ancestry. After initial single-locus analyses and subsequent meta-analysis with multiple testing correction for 29,963 single-nucleotide polymorphisms (SNPs), 11 SNPs remained statistically significant (p < 0.05). In the stepwise logistic regression analysis, three independent PanC risk-associated SNPs (KIF5B rs211304 C > G, FMN1 rs117648907 C > T, and MGAT3 rs34943118 T > C) remained statistically significant (p < 0.05), with odds ratios of 0.89 (95% confidence interval = 0.82-0.95 and p = 6.93 × 10

Indexed as

AgedCadherinsCase-Control StudiesFemaleForminsGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansKinesinsMaleMiddle AgedN-AcetylglucosaminyltransferasesPancreatic NeoplasmsPolymorphism, Single NucleotideQuantitative Trait Locibeta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferaseCadherinsForminsKIF5B protein, humanKinesinsN-Acetylglucosaminyltransferasescadherin pathwaypancreatic cancerrisk analysissingle-nucleotide polymorphism

Identifiers

PMID33200553
PMCPMC7774717
OpenAlexW3098118463

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.