Evidence map›Paper›PMID 33200351›Full record

ArticleJournal of autism and developmental disorders2021

Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings.

Jessie B Northrup, Nina B Leezenbaum, Susan B Campbell

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Research square · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jessie B NorthrupDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. northrupjb@upmc.edu.ORCID http://orcid.org/0000-0001-9863-9352
Nina B LeezenbaumDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Susan B CampbellDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
SYSTEMS CONNECTIVITY + BRAIN ACTIVATION:IMAGING STUDIES OF LANGUAGE + PERCEPTIONP50HD055748 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MINSHEW, NANCY J · 2007 to 2011
$9.7M
Early Social and Emotional Development in Toddlers at Genetic Risk for AutismR01MH091036 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMPBELL, SUSAN B · 2010 to 2014
$1.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD055748NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCRR NIH HHS UL1 RR024153NICHD NIH HHS P50 HD055748NIMH NIH HHS R01 MH091036
6 · The paper itself

Abstract

Social engagement, pretend play, and concern for another's distress represent fundamental features of typical social-emotional development in the second year. Children with autism spectrum disorder (ASD) display delays and deficits in these areas, and research on toddlers at heightened risk for ASD (HR; younger siblings of children with ASD) indicates these deficits may be apparent in toddlerhood. Prior research has examined these aspects of social-emotional development individually in HR toddlers. The present paper examines them jointly as predictors of ASD. We show that social engagement, pretend play, and empathic concern at 22-months each contribute uniquely to predicting later ASD diagnosis with high specificity and moderate sensitivity. Results have important implications for early diagnosis and intervention in young children with ASD.

Indexed as

Autism Spectrum DisorderChild, PreschoolEmotionsEmpathyHumansSiblingsSocial BehaviorAutism spectrum disorderEmpathic concernHigh-risk siblingsPretend playSocial engagement

Identifiers

PMID33200351
PMCPMC8124081
OpenAlexW3103908059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.