Evidence map›Paper›PMID 33200256›Full record

ArticlePflugers Archiv : European journal of physiology2021

Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC.

Christina Schnoz, Sandra Moser, Denise V Kratschmar, Alex Odermatt, Dominique Loffing-Cueni, Johannes Loffing

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Magnesium and Liver Metabolism Through the Lifespan.Advances in nutrition (Bethesda, Md.) · 2023
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christina SchnozInstitute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Sandra MoserInstitute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Denise V KratschmarDivision of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Alex OdermattDivision of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Dominique Loffing-CueniInstitute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Johannes LoffingInstitute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. johannes.loffing@anatomy.uzh.ch.ORCID 0000-0002-9415-6588
University of Zurich · CHUniversity of Basel · CHZHAW Zurich University of Applied Sciences · CH

Funding

Swiss National Science Foundation 310030_173276/1
6 · The paper itself

Abstract

The renal distal convoluted tubule (DCT) is critical for the fine-tuning of urinary ion excretion and the control of blood pressure. Ion transport along the DCT is tightly controlled by posttranscriptional mechanisms including a complex interplay of kinases, phosphatases, and ubiquitin ligases. Previous work identified the transcription factor Prox-1 as a gene significantly enriched in the DCT of adult mice. To test if Prox-1 contributes to the transcriptional regulation of DCT function and structure, we developed a novel mouse model (NCC

Indexed as

AnimalsAquaporin 2Gene DeletionGene Expression RegulationHomeodomain ProteinsKidney Tubules, DistalMagnesiumMicePotassiumProspero-Related Homeobox 1 ProteinSodiumSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3TRPM Cation ChannelsTumor Suppressor ProteinsAqp2 protein, mouseAquaporin 2Homeodomain ProteinsMagnesiumPotassiumProspero-Related Homeobox 1 ProteinSlc12a1 protein, mouseSlc12a3 protein, mouseSodiumSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3Trpm6 protein, mouseTRPM Cation ChannelsTumor Suppressor ProteinsDCT adaptationKidneyNaCl cotransporter (NCC)Renal distal convoluted tubule (DCT)Transcription factor Prox-1Transient receptor potential cation channel subfamily M member 6 (TRPM6)

Identifiers

PMID33200256
PMCPMC7782375
OpenAlexW3102880684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.