Evidence map›Paper›PMID 33200139›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Epidemiological and immunological features of obesity and SARS-CoV-2.

Eric J Nilles, Sameed M Siddiqui, Stephanie Fischinger, Yannic C Bartsch, Michael de Saint Aubin, Guohai Zhou, Matthew J Gluck, Samuel Berger, Justin Rhee, Eric Petersen and 21 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 8 institutions in 2 countries.

Eric J NillesBrigham and Women's Hospital, Boston, MA.
Sameed M SiddiquiComputational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA.
Stephanie FischingerRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Yannic C BartschRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Michael de Saint AubinHarvard Humanitarian Initiative, Boston, MA.
Guohai ZhouBrigham and Women's Hospital, Boston, MA.
Matthew J GluckSpace Exploration Technologies Corp, Hawthorne, CA.
Samuel BergerSpace Exploration Technologies Corp, Hawthorne, CA.
Justin RheeSpace Exploration Technologies Corp, Hawthorne, CA.
Eric PetersenSpace Exploration Technologies Corp, Hawthorne, CA.
Benjamin MormannBrigham and Women's Hospital, Boston, MA.
Michael LoescheBrigham and Women's Hospital, Boston, MA.
Zhilin ChenRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Jingyou YuRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Makda GebreRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Caroline AtyeoRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Matthew J GormanRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Alex Lee ZhuRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
John BurkeRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Matthew SleinRagon Institute of MGH, MIT and Harvard, Cambridge, MA.
Mohammad A HasdiandaBrigham and Women's Hospital, Boston, MA.
Guruprasad JambaulikarBrigham and Women's Hospital, Boston, MA.
Edward BoyerBrigham and Women's Hospital, Boston, MA.
Pardis SabetiMassachusetts Consortium on Pathogen Readiness, Boston, MA.
Dan H BarouchBroad Institute of MIT and Harvard, Cambridge, MA.
Boris D JulgBroad Institute of MIT and Harvard, Cambridge, MA.
Adam J KucharskiLondon School of Hygiene and Tropical Medicine, London.
Elon R MuskSpace Exploration Technologies Corp, Hawthorne, CA.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.
Galit AlterMassachusetts Consortium on Pathogen Readiness, Boston, MA.
Anil S MenonSpace Exploration Technologies Corp, Hawthorne, CA.
Ragon Institute of MGH, MIT and Harvard · USBrigham and Women's Hospital · USSpaceX (United States) · USBroad Institute · USHarvard University · USDana-Farber/Harvard Cancer Center · USLondon School of Hygiene & Tropical Medicine · GBMassachusetts Institute of Technology · US

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Kristian Graugaard Andersen · 2018 to 2026
$32.0M
Demystifying the antiviral activity of the IgG3+ antibody responseR37AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2015 to 2022
$5.8M
NIDA National Early Warning System Network (iN3): An Innovative ApproachR56DA038366 · NIDA · WRIGHT STATE UNIVERSITY · PI BOYER, EDWARD W, CARLSON, ROBERT GEOFFREY · 2014 to 2014
$300k
NIAID NIH HHS U19 AI135995NIDA NIH HHS R56 DA038366Wellcome Trust 206250/Z/17/Z
6 · The paper itself

Abstract

Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups.

Indexed as

COVID-19epidemiologyimmunityobesitySARS-CoV-2

Identifiers

PMID33200139
PMCPMC7668749
OpenAlexW3106231531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.