Evidence map›Paper›PMID 33200084›Full record

ArticleVirusdisease2020

Structure-guided discovery approach identifies potential lead compounds targeting M

Mohcine Elmessaoudi-Idrissi, Kyoko Tsukiyama-Kohara, Jalal Nourlil, Anass Kettani, Marc P Windisch, Michinori Kohara, Yashpal Singh Malik, Kuldeep Dhama, Soumaya Benjelloun, Sayeh Ezzikouri

Open access · bronzeAbstract read
In one paragraph

Article in Virusdisease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Mohcine Elmessaoudi-IdrissiVirology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc 1, Place Louis Pasteur, 20360 Casablanca, Morocco.
Kyoko Tsukiyama-KoharaTransboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Jalal NourlilMedical Virology and BSL3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Anass KettaniLaboratoire de Biologie Et Santé (URAC34), Département de Biologie, Faculté Des Sciences Ben Msik, Université Hassan II de Casablanca, Casablanca, Morocco.
Marc P WindischApplied Molecular Virology Laboratory, Discovery Biology Department, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea.
Michinori KoharaDepartment of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yashpal Singh MalikDivision of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh India.
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh India.
Soumaya BenjellounVirology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc 1, Place Louis Pasteur, 20360 Casablanca, Morocco.
Sayeh EzzikouriVirology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc 1, Place Louis Pasteur, 20360 Casablanca, Morocco.ORCID 0000-0002-3982-6163
Institut Pasteur du Maroc · MAIndian Veterinary Research Institute · INKagoshima University · JPInstitut Pasteur Korea · KRTokyo Metropolitan Institute of Medical Science · JPUniversity of Hassan II Casablanca · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing coronavirus disease 19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become fatal for the world with affected population crossing over 25 million in more than 217 countries, consequently declared a global pandemic by the World Health Organization. Unfortunately, neither specific prophylactic or therapeutic drugs nor vaccines are available. To address the unmet medical needs, we explored a strategy identifying new compounds targeting the main protease (M

Indexed as

COVID-19InhibitorsProteaseSARS-CoV-2TherapyZinc

Identifiers

PMID33200084
PMCPMC7656896
OpenAlexW3101856341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.