Evidence map›Paper›PMID 33200082›Full record

ArticleMolecular therapy. Methods & clinical development2021

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection.

Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Habiba S Alsafar, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
1.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  4. Is meningococcal B vaccination needed in the post-COVID-19 world?Biomedica : revista del Instituto Nacional de Salud · 2025
    Review
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  8. Review
  9. Structural aspects of CEACAM1 interactions.European journal of clinical investigation · 2024
    Review
  10. Article
  11. Review
  12. Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case Series.Pathobiology : journal of immunopathology, molecular and cellular biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Narjes Saheb Sharif-AskariSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Fatemeh Saheb Sharif-AskariSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Bushra MdkhanaSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Saba Al HeialyCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Habiba S AlsafarCenter for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Rifat HamoudiSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Qutayba HamidSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Rabih HalwaniSharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
University of Sharjah · AEKhalifa University of Science and Technology · AEKing Saud University · SAMohammed Bin Rashid University of Medicine and Health Sciences · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system is tightly regulated by the activity of stimulatory and inhibitory immune receptors. This immune homeostasis is usually disturbed during chronic viral infection. Using publicly available transcriptomic datasets, we conducted

Indexed as

CEACAM1COVID-19immune checkpoint inhibitorsimmune inhibitory receptorsinfluenza A viruslung autopsiesrespiratory viral infectionSARS-CoV-2sialic acidSIGLEC10

Identifiers

PMID33200082
PMCPMC7658590
OpenAlexW3105364689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.