Evidence map›Paper›PMID 33199858›Full record

ArticleNature human behaviour2021

Macro and micro sleep architecture and cognitive performance in older adults.

Ina Djonlagic, Sara Mariani, Annette L Fitzpatrick, Veerle M G T H Van Der Klei, Dayna A Johnson, Alexis C Wood, Teresa Seeman, Ha T Nguyen, Michael J Prerau, José A Luchsinger and 8 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature human behaviour, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 107 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 6 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 6 syntheses or guidelines pooled it, 164 citations in OpenAlex.

  1. Pooled it
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  5. Association of alternative polysomnographic features with patient outcomes in obstructive sleep apnea: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Pooled it
  6. Pooled it
  7. Comorbid insomnia and sleep apnea is associated with worse verbal episodic memory in older females.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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  16. NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 1 country.

Ina DjonlagicBeth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6951-3862
Sara MarianiHarvard Medical School, Boston, MA, USA.
Annette L FitzpatrickUniversity of Washington, Seattle, WA, USA.
Veerle M G T H Van Der KleiBrigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2782-1517
Dayna A JohnsonEmory University, Atlanta, GA, USA.
Alexis C WoodUSDA/ARS Children's Nutrition Center, Baylor College of Medicine, Houston, TX, USA.
Teresa SeemanUniversity of California, Los Angeles, Los Angeles, CA, USA.
Ha T NguyenWake Forest School of Medicine, Winston-Salem, NC, USA.
Michael J PrerauHarvard Medical School, Boston, MA, USA.
José A LuchsingerColumbia University Medical Center, New York, NY, USA.
Joseph M DzierzewskiDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Stephen R RappWake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Kristine YaffeWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Katherine E BurdickHarvard Medical School, Boston, MA, USA.
Katie L StoneCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Susan RedlineBeth Israel Deaconess Medical Center, Boston, MA, USA.
Shaun M PurcellHarvard Medical School, Boston, MA, USA. smpurcell@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-7402-5812
Brigham and Women's Hospital · USCalifornia Pacific Medical Center · USAtrium Health Wake Forest Baptist · USBeth Israel Deaconess Medical Center · USChildren's Nutrition Research Center at Baylor College of Medicine · USColumbia University Irving Medical Center · USEmory University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Washington · USVirginia Commonwealth University · USWake Forest University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Vascular Effects of Heparan Sulfate ProteoglycansP50HL056984 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 1997 to 2006
$13.1M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2016 to 2020
$12.2M
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityR01AG070867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M, REDLINE, SUSAN S. · 2021 to 2024
$9.9M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K01 HL138211NHLBI NIH HHS K23 HL103850NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS P50 HL056984NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NHLBI NIH HHS R01 HL146339NHLBI NIH HHS R21 HL145492NHLBI NIH HHS R24 HL114473NHLBI NIH HHS R35 HL135818NIAMS NIH HHS U01 AR066160NIA NIH HHS K23 AG049955NIA NIH HHS K24 AG045334NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG059303NIA NIH HHS R01 AG054081NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG070867NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIDDK NIH HHS P30 DK063491NIMHD NIH HHS R21 MD012738NIMH NIH HHS R03 MH108908NINDS NIH HHS R01 NS096177
6 · The paper itself

Abstract

We sought to determine which facets of sleep neurophysiology were most strongly linked to cognitive performance in 3,819 older adults from two independent cohorts, using whole-night electroencephalography. From over 150 objective sleep metrics, we identified 23 that predicted cognitive performance, and processing speed in particular, with effects that were broadly independent of gross changes in sleep quality and quantity. These metrics included rapid eye movement duration, features of the electroencephalography power spectra derived from multivariate analysis, and spindle and slow oscillation morphology and coupling. These metrics were further embedded within broader associative networks linking sleep with aging and cardiometabolic disease: individuals who, compared with similarly aged peers, had better cognitive performance tended to have profiles of sleep metrics more often seen in younger, healthier individuals. Taken together, our results point to multiple facets of sleep neurophysiology that track coherently with underlying, age-dependent determinants of cognitive and physical health trajectories in older adults.

Indexed as

CognitionAgedAged, 80 and overAge FactorsAgingCase-Control StudiesElectroencephalographyHumansMaleMetabolic SyndromeMiddle AgedSleepSleep, REM

Identifiers

PMID33199858
PMCPMC9881675
OpenAlexW3103535303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.