ArticleScientific reports2020
The maturity in fetal pigs using a multi-fluid metabolomic approach.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- A comprehensive genome-wide scan for parent-of-origin expressed genes in the pig clarifies the conservation landscape of genomic imprinting.Genetics, selection, evolution : GSE · 2026Article
- Metabolomic analysis of the endometrium of Large White and Meishan pigs reveals differences in biological processes during late gestation.BMC genomics · 2025Article
- Genetic regulation and variation of fetal plasma metabolome in the context of sex, paternal breeds and variable fetal weight.Open biology · 2025Article
- RNA-seq data of pig placenta and endometrium during late gestation.Data in brief · 2024Article
- Primiparous sow behaviour on the day of farrowing as one of the primary contributors to the growth of piglets in early lactation.Scientific reports · 2024Article
- Sex and fetal genome influence gene expression in pig endometrium at the end of gestation.BMC genomics · 2024Article
- Asterics: a simple tool for the ExploRation and Integration of omiCS data.BMC bioinformatics · 2023Article
- PlasmaScientific reports · 2023Article
- Creep Feeding and Weaning Influence the Postnatal Evolution of the Plasma Metabolome in Neonatal Piglets.Metabolites · 2023Article
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- Prenatal transcript levels and metabolomics analyses reveal metabolic changes associated with intrauterine growth restriction and sex.Open biology · 2022Article
- Major Reorganization of Chromosome Conformation During Muscle Development in Pig.Frontiers in genetics · 2021Article
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammalian species, the first days after birth are an important period for survival and the mortality rate is high before weaning. In pigs, perinatal deaths average 20% of the litter, with important economic and societal consequences. Maturity is one of the most important factors that influence piglet survival at birth. Maturity can be defined as the outcome of complex mechanisms of intra-uterine development and maturation during the last month of gestation. Here, we provide new insights into maturity obtained by studying the end of gestation at two different stages (3 weeks before term and close to term) in two breeds of pigs that strongly differ in terms of neonatal survival. We used metabolomics to characterize the phenotype, to identify biomarkers, and provide a comprehensive understanding of the metabolome of the fetuses in late gestation in three fluids (plasma, urine, and amniotic fluid). Our results show that the biological processes related to amino acid and carbohydrate metabolisms are critical for piglet maturity. We confirm the involvement of some previously described metabolites associated with delayed growth (e.g., proline and myo-inositol). Altogether, our study proposes new routes for improved characterization of piglet maturity at birth.
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