Evidence map›Paper›PMID 33199750›Full record

ArticleScientific reports2020

Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants.

Qinqing Chen, Huiqi Chen, Fangfang Xi, Matthew Sagnelli, Baihui Zhao, Yuan Chen, Mengmeng Yang, Dong Xu, Ying Jiang, Guangdi Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  10. Circadian Regulation of Lipid Metabolism during Pregnancy.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Qinqing ChenDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Huiqi ChenDepartment of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, China.
Fangfang XiDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Matthew SagnelliUniversity of Connecticut School of Medicine, Farmington, CT, USA.
Baihui ZhaoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Yuan ChenDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Mengmeng YangDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Dong XuDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Ying JiangDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China.
Guangdi ChenDepartment of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, China. chenguangdi@zju.edu.cn.
Qiong LuoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, China. luoq@zju.edu.cn.
Women's Hospital, School of Medicine, Zhejiang University · CNZhejiang University · CNUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neonates between 1 Jan 2014 and 31 Dec 2014. 5.6% neonates in our study were SGA. Serum samples were collected during second and third trimesters for evaluation on fasting lipids levels. The present study intended to explore the associations between maternal lipid profile and small-for-gestational-age neonates. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and adjusted via logistic regression analysis. After adjustments for confounders, third-trimester total cholesterol levels were associated with a decreased risk for small-for-gestational-age (aOR = 0.622, 95% CI 0.458-0.848, P = 0.002), and third-trimester high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were associated with an increased risk for small-for-gestational-age (aOR = 1.955, 95% CI 1.465-2.578, P < 0.001; aOR = 1.403, 95% CI 1.014-1.944, P = 0.041).In the highest gestational weight gain strata, especially the third-trimester, the effect of high-density lipoprotein cholesterol levels on the risk for small-for-gestational-age is larger. High high-density lipoprotein cholesterol level during third trimester could be considered as indicators of a high-risk of small-for-gestational-age, regardless of gestational weight gain.

Indexed as

AdultCholesterol, HDLFemaleGestational Weight GainHumansInfant, NewbornInfant, Small for Gestational AgeLipidsLogistic ModelsMaleMaternal AgeOdds RatioPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondCholesterol, HDLLipids

Identifiers

PMID33199750
PMCPMC7669834
OpenAlexW3105876732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.