ArticleScientific reports2020
Fusobacterium nucleatum in biopsied tissues from colorectal cancer patients and alcohol consumption in Korea.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of alcohol on gut microbial metabolism and the gut-liver-brain axis.Alcohol (Fayetteville, N.Y.) · 2026Review
- A Duplex qPCR Assay Targeting theInternational journal of molecular sciences · 2025Article
- Gut microbiota distinguishes aging hispanics with Alzheimer's disease: associations with cognitive impairment and severity.Scientific reports · 2025Article
- Exploring the Gut and Oral Microbiomes in Psychoactive Substance Use: A Scoping Review of Clinical Studies.Journal of neurochemistry · 2025Article
- The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis.Life (Basel, Switzerland) · 2025Review
- Investigation of the relationship betweenFrontiers in microbiology · 2025Article
- Oncolytic Virotherapies and Adjuvant Gut Microbiome Therapeutics to Enhance Efficacy Against Malignant Gliomas.Viruses · 2024Review
- Clinical relationships between the intratumoral microbiome and risk factors for head and neck cancer.Heliyon · 2024Article
- Alcohol and Periodontal Disease: A Narrative Review.Cureus · 2024Review
- Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model.Microbiology spectrum · 2024Article
- Alterations in colorectal cancer virome and its persistence after surgery.Scientific reports · 2024Article
- Exploring the interplay betweenFrontiers in microbiology · 2023Article
- Gut microbiota modulation: a tool for the management of colorectal cancer.Journal of translational medicine · 2022Review
- A positive feed-forward loop betweeniScience · 2022Article
- The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition.Frontiers in psychiatry · 2022Article
- Fusobacterium nucleatum: caution with interpreting historical patient sample cohort.Journal of pathology and translational medicine · 2021Article
- Review
- Review
- Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer.Frontiers in nutrition · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The roles of individual bacteria and their relationship in the development of colorectal cancer (CRC) remain unclear. We aimed to determine the prevalence of CRC-associated bacteria using quantitative real-time PCR (qPCR) or 16S rRNA analysis and the statistical correlations of patient demographics and clinical characteristics comprising alcohol consumption with CRC-associated bacteria. We determined the prevalence of five CRC-associated bacterial species in 38 CRC patients (39 samples) and 21 normal individuals using qPCR, and the relative abundance of bacterial taxa in the gut microbiome was assessed using 16S rRNA analysis. Fusobacterium nucleatum was the only bacterium that was significantly (P < 0.0001) more prevalent in the cancer tissue (82.1%) than in the normal tissue (0%) by qPCR. 16S rRNA analysis showed a significant correlation between six operational taxonomic units (OTUs), namely, the genera Fusobacterium, Peptostreptococcus, Collinsella, Prevotella, Parvimonas, and Gemella, in patients with CRC. An integrated analysis using 16S rRNA data and epidemiological characteristics showed that alcohol consumption was significantly correlated with the abundance of Fusobacterium OTUs. The correlation of alcohol consumption with the abundance of Fusobacterium OTUs in cancer tissue discovered using 16S rRNA analysis suggests a possible link between alcohol metabolism and subsequent tumorigenesis caused by F. nucleatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.