ArticleNature communications2020
Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
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- Poly(DADMAC) incorporated lipid nanoparticles enhance the delivery of antimicrobial peptides into plant cells.Scientific reports · 2026Article
- Article
- A Citrus medica stem cutting-based platform for rapid screening of therapeutic compounds against Candidatus Liberibacter asiaticus.Scientific reports · 2026Article
- High-efficiency genome-editing, transgene evaluation, and antimicrobial efficacy testing using Citrus medica L. hairy roots.The Plant journal : for cell and molecular biology · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- A secretory protein from "Autophagy · 2025Article
- Expression characteristics ofPlant signaling & behavior · 2025Article
- The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1-Mediated Sugar Accumulation and Cold Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A 'Candidatus Liberibacter asiaticus' effector SDE2470 facilitates citrus transcription factor CsVOZ2 degradation via BRUTUS E3 ligases.PLoS pathogens · 2025Article
- NPR1 suppresses Candidatus Liberibacter asiaticus-induced callose and reactive oxygen species accumulation.Plant physiology · 2025Article
- Field Performance of Novel Citrus Rootstocks Grafted with 'Valencia' Orange and Their Response to Systemic Delivery of Oxytetracycline.Plants (Basel, Switzerland) · 2025Article
- Amicoumacins produced by the native citrus microbiome isolateApplied and environmental microbiology · 2025Article
- Naturally occurring spinach defensins confer tolerance to citrus greening and potato zebra chip diseases.Plant biotechnology journal · 2025Article
- Article
- Recent progress in the understanding of Citrus Huanglongbing: from the perspective of pathogen and citrus host.Molecular breeding : new strategies in plant improvement · 2024Article
- Long intergenic non-coding RNAs modulate proximal protein-coding gene expression and tolerance to Candidatus Liberibacter spp. in potatoes.Communications biology · 2024Article
- Spatial chemistry of citrus reveals molecules bactericidal to Candidatus Liberibacter asiaticus.Scientific reports · 2024Article
- Genome editing of NPR3 confers potato resistance to Candidatus Liberibacter spp.Plant biotechnology journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major bottleneck in identifying therapies to control citrus greening and other devastating plant diseases caused by fastidious pathogens is our inability to culture the pathogens in defined media or axenic cultures. As such, conventional approaches for antimicrobial evaluation (genetic or chemical) rely on time-consuming, low-throughput and inherently variable whole-plant assays. Here, we report that plant hairy roots support the growth of fastidious pathogens like Candidatus Liberibacter spp., the presumptive causal agents of citrus greening, potato zebra chip and tomato vein greening diseases. Importantly, we leverage the microbial hairy roots for rapid, reproducible efficacy screening of multiple therapies. We identify six antimicrobial peptides, two plant immune regulators and eight chemicals which inhibit Candidatus Liberibacter spp. in plant tissues. The antimicrobials, either singly or in combination, can be used as near- and long-term therapies to control citrus greening, potato zebra chip and tomato vein greening diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.