Evidence map›Paper›PMID 33199702›Full record

ArticleScientific reports2020

Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo.

Sarah E Motta, Emanuela S Fioretta, Valentina Lintas, Petra E Dijkman, Monika Hilbe, Laura Frese, Nikola Cesarovic, Sandra Loerakker, Frank P T Baaijens, Volkmar Falk and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

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  12. Endothelial Progenitor Cell-BasedFrontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Sarah E MottaInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Emanuela S FiorettaInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Valentina LintasWyss Translational Center Zurich, University and ETH Zurich, Zurich, Switzerland.
Petra E DijkmanInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Monika HilbeInstitute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Laura FreseInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Nikola CesarovicDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Sandra LoerakkerDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Frank P T BaaijensDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Volkmar FalkDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Simon P HoerstrupInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.
Maximilian Y EmmertInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland. maximilian.emmert@irem.uzh.ch.
Swiss Institute for Regenerative Medicine · CHUniversity of Zurich · CHÉcole Polytechnique Fédérale de Lausanne · CHEindhoven University of Technology · NLDeutsches Herzzentrum der Charité · DEETH Zurich · CH

Funding

Swiss National Science Foundation PZ00P3_180138
6 · The paper itself

Abstract

Regenerative tissue-engineered matrix-based heart valves (TEM-based TEHVs) may become an alternative to currently-used bioprostheses for transcatheter valve replacement. We recently identified TEM-based TEHVs-geometry as one key-factor guiding their remodeling towards successful long-term performance or failure. While our first-generation TEHVs, with a simple, non-physiological valve-geometry, failed over time due to leaflet-wall fusion phenomena, our second-generation TEHVs, with a computational modeling-inspired design, showed native-like remodeling resulting in long-term performance. However, a thorough understanding on how TEHV-geometry impacts the underlying host cell response, which in return determines tissue remodeling, is not yet fully understood. To assess that, we here present a comparative samples evaluation derived from our first- and second-generation TEHVs. We performed an in-depth qualitative and quantitative (immuno-)histological analysis focusing on key-players of the inflammatory and remodeling cascades (M1/M2 macrophages, α-SMA

Indexed as

ActinsAnimalsBioprosthesisComputer-Aided DesignHeart ValvesHumansInflammationMacrophagesPhenotypeTissue EngineeringTranscatheter Aortic Valve ReplacementActins

Identifiers

PMID33199702
PMCPMC7669851
OpenAlexW3098420958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.