ArticleProceedings of the National Academy of Sciences of the United States of America2020
Evidence accumulation for value computation in the prefrontal cortex during decision making.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
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- Causal disconnectomics of motion perception networks: insights from transcranial magnetic stimulation-induced BOLD responses.The Journal of physiology · 2026Article
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- Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.NPJ systems biology and applications · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinations.bioRxiv : the preprint server for biology · 2025Article
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- Globus pallidus externus correlates with arousal in disorders of consciousness: a resting-state functional MRI study.Frontiers in neuroscience · 2025Article
- A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking.Nature human behaviour · 2025Article
- A multi-stage anticipated surprise model with dynamic expectation for economic decision-making.Scientific reports · 2024Article
- Positive correlation between measures of habitual responding and motivated responding in mice.Journal of the experimental analysis of behavior · 2024Article
- Value dynamics affect choice preparation during decision-making.Nature neuroscience · 2023Article
- Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes.Science advances · 2023Article
- Intention affects fairness processing: Evidence from behavior and representational similarity analysis of event-related potential signals.Human brain mapping · 2023Article
- Dorsolateral prefrontal cortex plays causal role in probability weighting during risky choice.Scientific reports · 2022Article
- Is the Dorsolateral Prefrontal Cortex Actually Several Different Brain Areas?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Evidence accumulation occurs locally in the parietal cortex.Nature communications · 2022Article
- Rat Anterior Cingulate Cortex Continuously Signals Decision Variables in a Patch Foraging Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key step of decision making is to determine the value associated with each option. The evaluation process often depends on the accumulation of evidence from multiple sources, which may arrive at different times. How evidence is accumulated for value computation in the brain during decision making has not been well studied. To address this problem, we trained rhesus monkeys to perform a decision-making task in which they had to make eye movement choices between two targets, whose reward probabilities had to be determined with the combined evidence from four sequentially presented visual stimuli. We studied the encoding of the reward probabilities associated with the stimuli and the eye movements in the orbitofrontal (OFC) and the dorsolateral prefrontal (DLPFC) cortices during the decision process. We found that the OFC neurons encoded the reward probability associated with individual pieces of evidence in the stimulus domain. Importantly, the representation of the reward probability in the OFC was transient, and the OFC did not encode the reward probability associated with the combined evidence from multiple stimuli. The computation of the combined reward probabilities was observed only in the DLPFC and only in the action domain. Furthermore, the reward probability encoding in the DLPFC exhibited an asymmetric pattern of mixed selectivity that supported the computation of the stimulus-to-action transition of reward information. Our results reveal that the OFC and the DLPFC play distinct roles in the value computation during evidence accumulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.