Evidence map›Paper›PMID 33199611›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

A microbial metabolite synergizes with endogenous serotonin to trigger

Yen-Chih Chen, Mohammad R Seyedsayamdost, Niels Ringstad

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  5. Chemical Genetics inACS chemical biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yen-Chih ChenSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016.ORCID 0000-0002-5110-7436
Mohammad R SeyedsayamdostDepartment of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0000-0003-2707-4854
Niels RingstadSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016; Niels.Ringstad@med.nyu.edu.ORCID 0000-0002-8679-2269
New York University · USPrinceton University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of sensory modulation of motor programsR35GM122573 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Niels Ringstad · 2017 to 2026
$5.7M
Implementing Innovative Approaches to Access the Hidden Metabolomes of BacteriaDP2AI124786 · NIAID · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2015 to 2015
$2.3M
NIAID NIH HHS DP2 AI124786NIGMS NIH HHS R35 GM122573NIH HHS P40 OD010440
6 · The paper itself

Abstract

Natural products are a major source of small-molecule therapeutics, including those that target the nervous system. We have used a simple serotonin-dependent behavior of the roundworm

Indexed as

Behavior, AnimalMicrobiotaSexual Behavior, AnimalSymbiosisAnimalsBiomarkersCaenorhabditis elegansCaenorhabditis elegans ProteinsGliotoxinNeuronsSerotoninBiomarkersCaenorhabditis elegans ProteinsGliotoxinSerotoninanimal–microbe interactionC. elegansserotonin

Identifiers

PMID33199611
PMCPMC7720207
OpenAlexW3102913644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.