Evidence map›Paper›PMID 33199604›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Glutaric acid production by systems metabolic engineering of an l-lysine-overproducing

Taehee Han, Gi Bae Kim, Sang Yup Lee

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 90 citations in OpenAlex.

  1. Enhanced production of l-histidine inSynthetic and systems biotechnology · 2026
    Article
  2. Article
  3. Review
  4. De novo biosynthesis of putrescine from glucose using engineeredSynthetic and systems biotechnology · 2026
    Article
  5. Article
  6. Review
  7. A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Article
  9. Obtaining PDC and other high-added value products from lignin byJournal of integrative bioinformatics · 2025
    Article
  10. Article
  11. Modular pathway engineering for enhanced production ofApplied and environmental microbiology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Metabolic engineering ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Reprogramming Metabolic Flux in Escherichia Coli to Enhance Chondroitin Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Taehee HanMetabolic and Biomolecular Engineering National Research Laboratory, Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Yuseong-gu, 34141 Daejeon, Republic of Korea.ORCID 0000-0002-8091-8801
Gi Bae KimMetabolic and Biomolecular Engineering National Research Laboratory, Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Yuseong-gu, 34141 Daejeon, Republic of Korea.ORCID 0000-0001-7563-5551
Sang Yup LeeMetabolic and Biomolecular Engineering National Research Laboratory, Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Yuseong-gu, 34141 Daejeon, Republic of Korea; leesy@kaist.ac.kr.ORCID 0000-0003-0599-3091
Korea Advanced Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing industrial demand for five-carbon platform chemicals, particularly glutaric acid, a widely used building block chemical for the synthesis of polyesters and polyamides. Here we report the development of an efficient glutaric acid microbial producer by systems metabolic engineering of an l-lysine-overproducing

Indexed as

Metabolic EngineeringSystems BiologyBatch Cell Culture TechniquesBiosynthetic PathwaysCorynebacterium glutamicumFermentationGlutaratesLysineMetabolic Flux AnalysisTranscriptomeGlutaratesglutaric acidLysineCorynebacterium glutamicumglutaric acidmetabolic engineeringmultiomics

Identifiers

PMID33199604
PMCPMC7720191
OpenAlexW3101292162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.